Model diagnostics for fitting QTL models to trait and marker data by interval mapping
HeredityPublished 1 September 1997
Christine A. Hackett
Citations5
SJR quartileQ2
SJR score1.07
SNIP1.32
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Abstract
Diagnostic tools are presented which enable the geneticist to assess the agreement between linkage data and a fitted normal mixture model for interval mapping. The theoretical likelihood profile along a chromosome is derived for a single quantitative trait locus (QTL) segregating in a backcross population, along with upper and lower bounds. This is useful for detecting two QTLs on a chromosome. Residuals are used to indicate the need for transformation of the trait values to a different scale before analysis, and the use of an incorrect distribution is shown to reduce the maximum lod score. A strategy for the regular use of diagnostic tools for interval mapping is presented.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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