Cushing's Syndrome due to Ectopic Production of Corticotropin-Releasing Factor
The Journal of Clinical Endocrinology & MetabolismPublished 1 March 1985Open access
Joseph L. Belsky, BEATRIZ CUELLO, L. W. Swanson, Donna M. Simmons, Robert M. Jarrett, Frank Braza
Citations115
SJR quartileQ1
SJR score2.18
SNIP1.77
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A patient with Cushing's syndrome is described who had a metastatic medullary carcinoma of the thyroid which contained corticotropin-releasing factor which was found by an immunohistochemical method in the patient's pituitary, but not in the thyroid tumor.
Abstract
A patient with Cushing's syndrome is described who had a metastatic medullary carcinoma of the thyroid which contained corticotropin-releasing factor. ACTH was found by an immunohistochemical method in the patient's pituitary, but not in the thyroid tumor. This is the second report demonstrating corticotropin-releasing factor in tumor tissue in this syndrome. Wider use of immunohistological methods can help distinguish this variety from other tumors associated with the ectopic ACTH syndrome when bioassays are not available.
Keywords
Medicine
NatureAlternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
2,133 Citations1982Susan Amara, Vivian Jonas +3 more
A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
The Journal of Clinical Endocrinology & MetabolismCause of Cushing's Syndrome in Patients with Tumors Arising from “Nonendocrine” Tissue
360 Citations1962Clifton K. Meador, Grant W. Liddle +5 more
It is concluded that certain tumors autonomously elaborate an ACTH-like substance that stimulates the adrenal glands to secrete large quantities of corticosteroids, which suppress the normal ACTh-secreting mechanism and, in addition, induce major ...
New England Journal of MedicineEctopic Secretion of Corticotropin-Releasing Factor as a Cause of Cushing’s Syndrome
284 Citations1984Robert M. Carey, Shalendra K. Varma +5 more
It is demonstrated that ectopic secretion of corticotropin-releasing factor is a cause of Cushing's syndrome in human beings.
PubMedThe ectopic ACTH syndrome.
215 Citations1965Grant W. Liddle, James R. Givens +2 more
The clinicopathological entity to which the name of the “ectopic ACTH syndrome” can no longer be considered a rarity, and through its action on the adrenal glands this ectopic hormone can cause all of the chemical and clinical abnormalities of Cushing9s syndrome.
Endocrine ReviewsEctopic (Inappropriate) Hormone Production by Tumors: Mechanisms Involved and the Biological and Clinical Implications*
183 Citations1980Stephen B. Baylin, Geoffrey Mendelsohn
This work has shown that a wide range of endocrine tumors secrete hormones not normally associated with the gland in which the neoplasm arises and that nonendocrine tumors can synthesize and/or secrete certain polypeptide hormones and other “tumor-associated” proteins.
New England Journal of MedicineEvidence for the Presence of Tumor Peptides with Corticotropin-Releasing-Factor-like Activity in the Ectopic ACTH Syndrome
167 Citations1971G. Virginia Upton, Thomas Amatruda
Assays in hypophysectomized rats demonstrated that these peptides were devoid of direct adrenal-stimulating activity, and Amino acid content indicates that these products are peptide in nature and different in composition from conventional corticotropin-releasing-factor-like products.
European Journal of EndocrinologyMEDULLARY THYROID CARCINOMA: ECTOPIC PRODUCTION OF PEPTIDES WITH ACTH-LIKE, CORTICOTROPHIN RELEASING FACTOR-LIKE AND PROLACTIN PRODUCTION-STIMULATING ACTIVITIES
90 Citations1976J.C. Birkenhäger, G. Virginia Upton +3 more
A large arterio-venous increase in plasma corticotrophin releasing factor-like activity across the thyroid gland was observed and tumour tissue contained corticOTrophinleasing factor- like activity and can explain the Cushing's syndrome and the galactorrhoea both of which disappeared completely after thyroidectomy.
CancerMedullary cancer of the thyroid gland associated with hypercorticism
82 Citations1969I. Szijj, Zsolt Csapó +2 more
The authors believe that the thyroid carcinoma produced a peptide having ACTH activity, and this was responsible for the development of the hypercorticism in a 39‐year‐old man with a metastasizing medullary carcinoma of the thyroid gland containing amyloid.
The Journal of Clinical Endocrinology & MetabolismMedullary Carcinoma of the Thyroid—A Cause of Cushing's Syndrome: Report of Two Cases<sup>1</sup>
71 Citations1968GEORGE F. DONAHOWER, O. P. Schumacher +1 more
Two case reports are presented concerning Cushing's syndrome that was associated with thyroid carcinoma of the uncommon medullary type, in one neoplasm in pure form, in the other mixed with follicular elements.
The Journal of Clinical Endocrinology & MetabolismAdrenocorticotropin, β-Lipotropin, β-Endorphin, and Corticotropin-Releasing Factor-Like Activity in an Adrenocorticotropin-Producing Nephroblastoma
54 Citations1980Kozo Hashimoto, Jiro Takahara +6 more
The Journal of Clinical Endocrinology & MetabolismCorticotropin-Releasing Factor-like Activity in ACTH Producing Tumors
49 Citations1977Toshihiro Suda, Hiroshi Demura +5 more
PubMedCorticotrophin-secreting carcinomas.
48 Citations1966J. L. H. O’Riordan, Gerald Blanshard +2 more
The Journal of Clinical Endocrinology & MetabolismACTH-Secreting Medullary Carcinoma of the Thyroid Presenting as Severe Idiopathic Osteoporosis and Senile Purpura: Report of a Case and Review of the Literature*
40 Citations1978EDWARD M. ROSENBERG, Theodore J. Hahn +3 more
In contrast to the usual presentation of the ectopic ACTH syndrome as primarily hypokalemic alkalosis and glucose intolerance, patients with relatively benign and indolent ACTH-secreting tumors, such as certain cases of medullary carcinoma of the thyroid, may present with more typical signs and symptoms of Cushing's syndrome.
New England Journal of MedicineCushing's Disease
28 Citations1959Burton C. Dyson
The interrelations of several uncommon diseases in an individual patient may be obscure and speculative when considered in the isolated case, but when others recall and report similar cases significant connections are made.
European Journal of EndocrinologySTEROID HORMONE PRODUCTION IN A CASE OF CUSHING'S SYNDROME WITH ELECTROLYTE CHANGES SIMULATING PRIMARY ALDOSTERONISM
19 Citations1959B. Hökfelt, Björn Sjögren +1 more
CancerACTH-secreting medullary carcinoma of the thyroid: Monitoring of clinical course with calcitonin and cortisol assays and immunohistochemical studies
16 Citations1980Jacques Jolivet, Hugues Beauregard +2 more
The clinical course of a patient with Cushing's syndrome secondary to metastatic medullary carcinoma of the thyroid was documented with serial calcitonin and cortisol assays and tumor immunohistochemistry studies, showing almost total disappearance of ACTH‐reacting cells.
The Journal of UrologyCushing’s Syndrome Associated with Anaplastic Carcinoma of the Thyroid Gland
14 Citations1966E. Everett Anderson, James F. Glenn