Identification of a somatostatin- 14-generating propeptide converting enzyme as a member of the kex2/furin/PC family
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TL;DR
Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids, suggesting that the kex2/furin/PC protease family is involved in propeptide conversion.
Abstract
A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.