The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions
Biochemical and Biophysical Research CommunicationsPublished 1 January 1984
Georges Romey, Michel Lazdunski
Citations190
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
These two Ca2+-dependent K+ channels coexist in rat muscle cells in culture but also probably in many other cellular types.
Abstract
Ca2+-dependent K+ channels responsible for the long-lasting after-hyperpolarization in rat muscle cells in culture are not those extensively studied by the patch-clamp technique. The first ones are blocked by apamin, a bee venom polypeptide, and they are unaffected by tetraethylammonium (TEA) whereas the second ones are blocked by TEA and unaffected by apamin. These two Ca2+-dependent K+ channels coexist in rat muscle cells in culture but also probably in many other cellular types.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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