Effect of a Non-European (Nigerian) meal on the bioavailability of nitrofurantoin in man
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TL;DR
It is suggested that fatty meals may enhance the therapeutic efficacy of nitrofurantoin in man after an overnight fast and immediately following a fatty meal of fried plantains and egg stew.
Abstract
The effect of a Non-European (Nigerian) meal on the bioavailability of nitrofurantoin was investigated in man. In the study 8 healthy volunteers received each a single 100 mg dose of the drug orally after an overnight fast on one occasion and on another occasion immediately following a fatty meal of fried plantains and egg stew. Urine was collected before and for 24 h after drug administration. The bioavailability of the drug was evaluated from the urinary excretion data of the unchanged drug. It was found that the meal significantly increased (P < 0.05) only the extent of absorption of nitrofurantoin, while the rate of absorption of the drug caused by the meal was not significantly increased. It is suggested that fatty meals may enhance the therapeutic efficacy of nitrofurantoin in man.