Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol
Biochemical and Biophysical Research CommunicationsPublished 1 October 1973
Zafarul H. Beg, David W. Allmann, D. M. Gibson
Citations308
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity is diminished in several in vitro liver systems preincubated in the presence of cAMP, and can be partially restored by incubation with a second protein fraction of the cytosol.
Abstract
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity is diminished in several in vitro liver systems preincubated in the presence of cAMP. Reductase activity in isolated, washed liver microsomes is inactivated by ATP, Mg++, and a protein fraction separated from the liver cytosol. This effect is augmented by 3′–5′ cyclic AMP. Reductase activity in previously inactivated microsomes can be partially restored by incubation with a second protein fraction of the cytosol.
Keywords
Biochemistry, Genetics and Molecular Biology
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