Drug effects and initial severity of symptomatology
PsychopharmacologyPublished 1 January 1965
Seymour Fisher, Ronald S. Lipman, E. H. Uhlenhuth, Karl Rickels, Lee C. Park
Citations34
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
Data are presented to show that, with meprobamate and placebo in neurotic outpatients, the magnitude of the pharmacological effect remains constant across all levels of initial severity.
Abstract
A recurring question appearing in clinical psychopharmacological research concerns the nature of the relationship between initial severity of symptomatology and the magnitude of a drug effect. Data are presented to show that, with meprobamate and placebo in neurotic outpatients, the magnitude of the pharmacological effect remains constant across all levels of initial severity.
Keywords
PsychologyMedicineNeuroscience
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Three major techniques for statistically handling LIV are reviewed and the proposed criterion of a satisfactory score is: the correlation between the initial level and a properly corrected score should be zero, and the adjusted score should have face validity.
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During the course of follow-up studies on patients who participated in an extensive outpatient, short-term psychotherapy research project, the opportunity presented itself for the investigation of the response to brief trials on placebo in certain members of this population.