Regulation of <i>wingless</i> transcription in the <i>Drososphila</i> embryo
DevelopmentPublished 1 January 1993
Philip W. Ingham, Alicia Hidalgo
Citations136
SJR quartileQ1
SJR score1.72
SNIP0.98
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TL;DR
It is shown that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes, and that most other aspects of wG expression are independent of this regulatory network.
Abstract
The segment polarity gene wingless (wg) is expressed in a complex pattern during embryogenesis suggesting that it plays multiple roles in the development of the embryo. The best characterized of these is its role in cell pattening in each parasegment, a process that requires the activity of other segment polarity genes including patched (ptc) and hedgehog (hh). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show that most other aspects of wg expression are independent of this regulatory network.
Keywords
Biochemistry, Genetics and Molecular Biology
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