Increased Activity of Digoxin-Like Substance in Low-Renin Hypertension in Acromegaly
Clinical and Experimental Hypertension Part A Theory and PracticePublished 1 January 1990
Piotr Soszyński, Jadwiga SlSowińska-Srzednicka, S Zgliczyński
Citations8
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TL;DR
The activity of DLS correlated positively with mean arterial pressure and negatively with plasma renin activity, but not with growth hormone levels, and may play a role in the pathogenesis of low-renin hypertension in acromegaly.
Abstract
an endogenous sodium pump inhibitor/digoxin-like substance may play a role in the pathogenesis of low-renin hypertension in acromegaly.
Keywords
Medicine
Annals of Internal MedicineAn Endogenous Digoxin-Like Substance in Patients with Renal Impairment
248 Citations1983Steven W. Graves, BECKY BROWN +1 more
The data suggest that a substance with digoxin-like immunoactivity is present in many patients with renal insufficiency and this substance may seriously compromise the accuracy and interpretation of digoxin concentration measurements.
New England Journal of MedicineCellular Sodium Transport in Essential Hypertension
205 Citations1986Franklin H. Epstein, P. J. Hilton
The Journal of Clinical Endocrinology & MetabolismSODIUM RETENTION WITH HUMAN GROWTH HORMONE AND ITS SUBFRACTIONS*†
110 Citations1961Edward G. Biglieri, Charles O. Watlington +1 more
Results indicate that sodium retention with human growth hormone in man is independent of aldosterone secretion, and the magnitude of sodium retention was increased in primary aldosteronism, possibly because of the potassium-depleted state.
The Journal of Clinical Endocrinology & MetabolismAn Endogenous Ouabain-Like Factor Associated with Hypertensive Pregnant Women*
86 Citations1984Steven W. Graves, Gordon H. Williams
There was a significant correlation between the diastolic blood pressures of these women at the time of amniocentesis and the amniotic fluid OLF levels determined by either assay, consistent with OLF having a role in hypertensive complications of pregnancy.
New England Journal of MedicineEvidence of an Endogenous Digitalis-like Factor in the Plasma of Patients with Acromegaly
64 Citations1987Gilbert Deray, M Rieu +5 more
It is concluded that an endogenous digitalis-like factor is present in the plasma of patients with chronic volume expansion due to acromegaly, consistent with the hypothesis that this natriuretic factor may have a physiologic role in water and sodium homeostasis.
Clinical Pharmacology & TherapeuticsAn improved method of estimating digoxin in human plasma
63 Citations1970Åke Bertler, Arne Redfors
A clinically useful method for determination of digoxin in plasma is described, based on the ability of digitalis glycosides to inhibit the transport of 86Rb into erythrocytes, and some clinical findings are presented.
European Journal of EndocrinologyAcromegaly and hypertension: role of the renin-angiotensin-aldosterone system
46 Citations1982Bengt E. Karlberg, Anna-Maria Ottosson
European Journal of EndocrinologyREVERSIBLE PLASMA AND RED BLOOD CELLS VOLUMES INCREASES IN ACROMEGALY
43 Citations1977G Strauch, A. Lego +2 more
It is concluded from data and other experimental evidence that endogenous GH hypersecretion is responsible for the reversible PV and RBCV increases frequently found in acromegalic patients.
Biochemical and Biophysical Research CommunicationsPresence of digitalis-like factor in mammalian plasma
34 Citations1988Atsuo Goto, Kaoru Yamada +5 more
A highly polar [3H] ouabain displacing compound was purified to a high degree using a combination of chromatographic procedures including reverse phase and gel filtration high performance liquid chromatography to monitor digitalis-like activity.
PubMedProgesterone derivatives that bind to the digitalis receptor: effects on Na+,K+-ATPase and isolated tissues.
34 Citations1985LaBella Fs, I. Bihler +4 more
Body tissues possess the enzymes for conversion of PROG to derivatives related even more closely than the semisynthetic CMA to the CG configuration, and PROG derivatives related to CMA appear to be likely candidates for endogenous digitalis-like hormones.
Journal of Cardiovascular PharmacologyPlasma Sodium Pump Inhibitor in Essential Hypertension and Normotensive Subjects with Hypertensive Heredity
32 Citations1984Hugues de Thé, Marie‐Aude Devynck +4 more
The data show the existence of a sodium pump inhibitor in the plasma of some subjects and point to a possible association with hypertension, and underline the importance of genetic background and the heterogeneity of essential hypertension.
PubMedEvidence for a circulating endogenous Na+-K+ pump inhibitor in low-renin hypertension.
32 Citations1985Haddy Fj, Pamnani Mb
It is suggested that an endogenous Na+,K+-ATPase inhibitor might participate in the genesis of certain forms of ren hypertension, and efforts to determine the chemical structure of the agent or agents should be intensified.
American Journal of Clinical PathologyVariable Cross-reactivity of Digoxin Metabolites in Digoxin Immunoassays
30 Citations1984Roland Valdes, Becky A. Brown +1 more
It is concluded that digoxin metabolites in serum are measured to various extents as the parent digoxin compound by all of the immunoassays they studied and may help to explain the discrepancies in correlation of clinical response to measured serum digoxin values reported in other studies.
Clinical EndocrinologyLEUCOCYTE SODIUM TRANSPORT IN ACROMEGALY
28 Citations1987Leong L. Ng, D J Evans
GH, in vitro, stimulated ouabain‐sensitive efflux in leucocytes at a concentration of 25 mU/1.0 and it is proposed that this action of GH may explain the sodium and calorigenic effects and possibly the stimulation of amino acid uptake by the hormone.
Journal of Molecular MedicineA quantitative receptor assay for “digitalis-like” compounds in serum. Demonstration of raised concentrations in essential hypertension and correlation with arterial blood pressure
25 Citations1987Kristin Moreth, D Renner +1 more
The influence of serum from patients with essential hypertension on [3H]ouabain binding to isolated (Na++K+)-ATPase and on the reactivity with digoxin-specific antibodies was investigated and it was possible to quantify this “digitalis-like” factor with a receptor assay in ouabain equivalents.
European Journal of BiochemistryFurther biochemical characterization of an Na<sup>+</sup> pump inhibitor purified from human urine
23 Citations1987Maryse Crabos, Marie‐Laure Grichois +3 more
Endalin is a reversible and partial specific inhibitor of Na+,K+-ATPase, its Na+K- ATPase inhibition closely resembles that of ouabain and it could be considered as one of the natriuretic hormones.
PubMedRelationships among endogenous digitalis-like factors in essential hypertension.
23 Citations1985JM Hamlyn, Levinson Pd +5 more
The data indicate the presence of two classes of digitalis-like factors with potentially different roles in electrolyte metabolism and hypertension, which are thought to act by partial inhibition of active sodium transport, thereby promoting increased intracellular levels of Na+ and Ca2+ in a variety of cell types.
The Journal of Clinical Endocrinology & MetabolismAbnormal Adrenal and Vascular Responses to Angiotensin II and an Angiotensin Antagonist in Acromegaly*
22 Citations1980Thomas J. Moore, WINSTON THEIN-WAI +4 more
To test the possibility that the hypertension commonly seen in acromegaly could be due to abnormalities in the patients’ sensitivities to angiotensin II (A II), such as have recently been described in some subgroups of essential hypertensives, the adrenal and vascular responses to endogenous and exogenous A II and to angiotsin blockade (saralasin) are studied.
PubMedBile salts as endogenous digitalis like factors.
19 Citations1986Sudesh Vasdev, L. Longerich +4 more
The bile salts appear to be examples of endogenous digitalis like compounds which do not act by simple competitive ligand binding to antidigoxin antibody and Na,K-ATPase, and make an important contribution todigitalis like factor activity in bile, but not in plasma.
PubMedIntracellular sodium, potassium and magnesium concentration, ouabain-sensitive 86rubidium-uptake and sodium-efflux and Na+, K+-cotransport activity in erythrocytes of normal male subjects studied on two occasions.
18 Citations1986Paul Lijnen, Peter Hespel +4 more
Both the red cell sodium and potassium concentration, the erythrocyte ouabain-sensitive 86Rb-uptake and Na+-efflux, the furosemide-sensitive Na+ and K+- efflux and the ethacrynic acid-sensitive 85Rb -uptake are stable over time in the same individual.
Clinical BiochemistryA study of lipid effects on the digoxin immunoassay and on the binding to and activity of Na+/K+-ATPase
17 Citations1986Angela K. Young, E. Giesbrecht +1 more
Of the monoglycerides studied mono-11-eicosenoin was found to cross-react in the digoxin immunoassay, inhibit red cell 86Rb uptake and displace 3H-ouabain from its receptor, membrane-bound Na+/K+-ATPase.
Clinical and Experimental Hypertension Part A Theory and PracticeIn Vitro Action of Insulin on Erythrocyte Sodium Transport Mechanisms: Its Possible Role in the Pathogenesis of Arterial Hypertension
16 Citations1988R Tedde, Leonardo A. Sechi +3 more
Results show that insulin inhibits Na+K+ pump, while Na+,K+ cotransport is markedly activated, and the possible link between pathogenesis of arterial hypertension in hyperinsulinemic subjects and present data is examined.
Clinical and Experimental Hypertension Part A Theory and PracticeHigh Blood Pressure and Hyperinsulinaemia in Acromegaly and in Obesity
14 Citations1989J. Słowńska-srzednicka, S Zgliczyński +3 more
The results indicate that insulin may play a role in the regulation of blood pressure in essential hypertension, and in such hyperinsulinaemic disorders as acromegaly and obesity.
Clinical and Experimental Hypertension Part A Theory and PracticeThe Concept of The Natriuretic Hormone And Its Relation To Hypertension
14 Citations1985H. E. de Wardener
It is proposed that in essential hypertension a genetic abnormality of the kidney causes a difficulty in excreting sodium, which leads to an initial blood volume expansion which causes the observed rise in the plasma's capacity to inhibit sodium transport, and to the increased vascular tone.
Clinical and Experimental Hypertension Part A Theory and PracticeGrowth Hormone (GH) Secretion During Nocturnal Sleep and after Clonidine in Patients with Essential Hypertension
3 Citations1988J. Slsowińnska-Srzednicka, S. Zgliczńanski +3 more
A strong and significant correlation demonstrated between the maximal GH concentration during the nocturnal sleep and after clonidine suggests that the mechanism of GH inhibition in response to both these stimuli is similar and it probably is related to the inhibition of neurohormonal secretion of the growth hormone releasing factor (GRF).