Herpes simplex encephalitis

Journal of the Neurological SciencesPublished 1 May 1984

Margaret M. Esiri, A. H. Tomlinson

DOI10.1016/0022-510x(84)90039-x

Source URL

Citations63

SJR quartileQ1

SJR score1.15

SNIP0.99

TL;DR

The ease of access of virus infecting the face to the olfactory system shown in this model may have implications for human infections.

Abstract

An immunohistological study of viral antigen (VA) in the brain was carried out in mice which had been infected with herpes simplex type 1 virus (HSV) in the skin of the face. In 77% of the mice with VA in the brain the olfactory system as well as the trigeminal system/brainstem was affected. The remaining 23% had VA in the trigeminal system/brainstem only. Eye swab cultures yielded HSV from all mice with VA in the olfactory system. The ease of access of virus infecting the face to the olfactory system shown in this model may have implications for human infections.

Keywords

MedicineNeuroscience

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