Late effects of childhood cancer therapy
Pediatric Clinics of North AmericaPublished 1 October 2002
Debra L. Friedman, Anna T. Meadows
Citations113
SJR quartileQ2
SJR score0.72
SNIP0.96
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TL;DR
This study reviews the common long-term sequalae of childhood cancer and its therapy and discusses the clinical and research challenges posed by such late effects.
Abstract
This study reviews the common long-term sequalae of childhood cancer and its therapy. It discusses the clinical and research challenges posed by such late effects. The authors address related topics of late effects research and clinical care, methodological issues, barriers and directions for the future.
Keywords
Medicine
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One-way analyses of variance on the dependent measures indicate that the children with severe medical late effects have a poorer total self-concept, more depressive symptoms, and a more external locus of control than those with no or mild-to-moderate late effects.
Journal of Clinical OncologyEffects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia.
182 Citations1984Julia H. Rowland, Oliver Glidewell +8 more
Children whose CNS prophylaxis included cranial irradiation attained significantly lower mean Full Scale IQs, performed more poorly on the Wide Range Achievement Test, a measure of school abilities, and exhibited a greater number of difficulties on a variety of other neuropsychologic measures.
The American Journal of CardiologyClinical and angiographic features of coronary artery disease after chest irradiation
176 Citations1987Paul T. McEniery, Khosrow Dorosti +3 more
Radiation-associated CAD is characterized by a high incidence of left main and right ostial coronary disease and often occurs in women with relatively few conventional risk factors for CAD.
CancerThe effects of different cumulative doses of chemotherapy on testicular function. Results in 75 patients treated for Hodgkin's disease during childhood or adolescence
172 Citations1990Jürgen Brämswig, Ulrike Heimes +4 more
Circumstantial evidence indicates that procarbazine is the major gonadotoxic agent involved in chemotherapy for Hodgkin's disease affecting Leydig cell function as well as spermatogenesis.
CancerThe cardiotoxicity of adriamycin and daunomycin in children
171 Citations1976Angela C. Gilladoga, Corazon Manuel +4 more
Eight of 50 children receiving adriamycin and 2 of 60 receiving daunomycin had severe cardiomyopathy with congestive heart failure and the incidence was significantly higher in those who also had incidental cardiac radiation.
Journal of Clinical OncologyLong-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas.
169 Citations1993Rodger M. Pryzant, Marvin L. Meistrich +3 more
Pelvic XRT and cumulative cyclophosphamide dosages greater than 9.5 g/m2 are associated with a high risk of permanent sterility in lymphoma patients treated with the CHOP-Bleo regimen.
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