Group A Streptococcal Infections and Acute Rheumatic Fever
New England Journal of MedicinePublished 12 September 1991
A L Bisno
Citations453
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
The most frequent of which are acute pharyngitis and streptococcus-related diarrhoea and pneumonia.
Abstract
STREPTOCOCCUS PYOGENES (group A streptococcus) is one of the most common and ubiquitous of human pathogens. It causes a wide array of infections, the most frequent of which are acute pharyngitis ("strep throat") and impetigo (pyoderma). Other manifestations of infection with group A streptococcus include sinusitis, otitis, peritonsillar and retropharyngeal abscess, pneumonia, scarlet fever, erysipelas, cellulitis, lymphangitis, puerperal sepsis, vaginitis, myositis, gangrene, and perianal cellulitis. The organism has, moreover, long been the focus of intense clinical and investigative interest because of its association with two nonsuppurative sequelae: acute rheumatic fever and acute glomerulonephritis. Infections caused by group A streptococci were . . .
Keywords
Medicine
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197 Citations1988E. T. Gaworzewska, G. Colman
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191 Citations1986Elía M. Ayoub, D J Barrett +2 more
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170 Citations1989Ashwani Khanna, Daniel R. Buskirk +8 more
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157 Citations1988B. F. Massell, Christopher G. Chute +2 more
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73 Citations1991KIRAN BELANI, Patrick M. Schlievert +2 more
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73 Citations1985Subhash Chaudhary, Sandra A. Bilinsky +5 more
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59 Citations1987A L Bisno, D E Craven +1 more
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54 Citations1990Robert R. Tanz, Stanford T. Shulman +4 more
It is concluded that beta-lactamase production by normal pharyngeal flora does not fully explain the failure of penicillin therapy for acute streptococcal pharyngitis and using an antibiotic effective against beta- lactam enzyme-producing bacteria will not eliminate the problem of bacteriologic treatment failure.
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52 Citations1985Neil L. Barg, Mary Ann Kish +2 more
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47 Citations1988Rebekah Thomas, David E. Conwill +4 more
The history of prophylactic penicillin use among U.S. Navy and Marine Corps recruits and the rationale for continuing this practice today are reviewed.
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46 Citations1983E H Beachey, Jerome M. Seyer +2 more
It is demonstrated that the repeating covalent structures of native and chemically synthesized polypeptide fragments of streptococcal M protein possess several unique as well as repeating epitopes that evoke opsonic and presumably protective, but not heart cross-reactive, antibodies against a rheumatogenic strain of S. pyogenes.
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43 Citations1990Josip Begovae, E Márton +4 more
Clinical Infectious DiseasesStructure, Function, and Genetics of Streptococcal M Protein
41 Citations1988Vincent A. Fischetti, Kevin F. Jones +2 more
DNA sequence analysis of the M gene in size mutants derived from a single strain suggests that sequence changes which result from homologous recombination may play a role in the antigenic variation of M protein.
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41 Citations1983E H Beachey, W A Simpson +4 more
Although streptococci exhibit LTA-sensitive binding to phagocytic cells in a serum-free system, in the presence of serum, they do not; rather, complement bound to the strePTococcal cell surface is required for recognition by phagocytes.
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40 Citations1988T. Bartter
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40 Citations1977A. L. Bisno, Ian Pearce +1 more
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39 Citations1986Howard Fillit, Maclyn McCarty +1 more
HAluronate was shown to be immunogenic in rabbits and inhibited the immune rabbit sera reaction to streptococcal hyaluronate, demonstrating crossreactivity of these molecules.
The Journal of PediatricsEfficacy of benzathine penicillin G in group A streptococcal pharyngitis: Reevaluation
38 Citations1987Sandor Feldman, Alan L. Bisno +3 more
It was found GABS eradication rates to exceed 10% in children given benzathine penicillin G, and the failure rate did not appear to be related to enrichment of the patient population with a high proportion of asymptomatic carriers nor to the presence ofPenicillin-tolerant GABS.
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37 Citations1990Michael Dan, S. Maximova +3 more
The clinical experience and literature review show that the presentation of group A streptococcal bacteremia is diverse, with transient bactseremia of uncertain clinical significance on one end of the spectrum and overwhelming sepsis on the other.
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36 Citations1986X Berríos, Felipe Quesney +4 more
Despite the fact that ARF and AGN were occurring in the same neighborhoods and among families of equivalent size and socioeconomic status, the pharyngeal isolation rates of group A streptococci were significantly lower among patients with ARF
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This study confirms the observations of others that administration of penicillin lowers the probability that a person who acquires group A Streptococcus will develop type-specific antibody.
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33 Citations1935Alvin F. Coburn, Ruth Pauli
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32 Citations1988Mario J. Marcon, M M Hribar +5 more
Antimicrobial susceptibility tests performed with 40 mucoid and 40 nonmucoid isolates against penicillin and nine other antimicrobial agents showed all strains to be susceptible, with no difference in MICs.
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32 Citations1974Robert W. Quinn, Charles F. Federspiel
The Pediatric Infectious Disease JournalAcquisition of Group A streptococcal M protein antibodies
31 Citations1985R. Quinn, ROGER VANDER ZWAAG +1 more
One-third of the 75 children who acquired positive throat cultures had a significant rise in anti-strzeptolysin O or anti-hyaluronidase antibody titers, and the presence of strain-specific serum M protein antibodies did not appear to be protective.
Infection and ImmunityActivation of the alternative complement pathway by a streptococcal lipoteichoic acid
30 Citations1978B A Fiedel, Robert W. Jackson
A glycerol lipoteichoic acid antigen from Streptococcus pyogenes 1-RP41 was found by rabbit erythrocyte hemolytic assay to activate the alternative complement pathway in human sera.
The Journal of Infectious DiseasesBacteremia Caused by Group G Streptococci in Parenteral Drug Abusers: Epidemiological and Clinical Aspects
30 Citations1986D. E. Craven, Ann I. Rixinger +3 more
Journal of InfectionVirulent Streptococcus pyogenes: Outbreak and spread within a geriatric unit
28 Citations1983Ross Reid, Roger Briggs +2 more
An outbreak of infection due to Streptococcus pyogenes occurred in a geriatric rehabilitation unit between February and September 1981, affecting 10 patients and two staff.
The Journal of Experimental MedicineImmunogenicity of liposome-bound hyaluronate in mice. At least two different antigenic sites on hyaluronate are identified by mouse monoclonal antibodies.
27 Citations1988Howard Fillit, Marea J. Blake +2 more
The results confirm that HA is immunogenic and suggest that the mode of presentation of HA is important for the induction of the immune response, and in HA antigenicity, and should facilitate immunologic studies of HA.
Clinical PediatricsIncidence of Acute Rheumatic Fever
26 Citations1983Richard H. Schwartz, Seymour I. Hepner +1 more
This study documents the diagnosis of the disease in 23 middle-class children from Fairfax County, Virginia, during the 11-year- period from 1970 through 1980, which has one of the highest median family incomes in the United States.
The Journal of Experimental MedicineDifference in the structural features of streptococcal M proteins from nephritogenic and rheumatogenic serotypes.
24 Citations1987Kiran Khandke, Thomas Fairwell +1 more
Findings suggest an underlying conservation of the tertiary structure of the various M protein serotypes, despite the complexity in their antigenic variation and suggest that the nephritogenic Mprotein serotypes M1 and M49 may be further apart evolutionarily from the rheumatogenic serotypes 5, 6, and 24.
QJMSeptic Scarlet Fever due to <italic>Streptococcus pyogenes</italic> Cellulitis
24 Citations1988Sunil Shaunak, Julia Wendon +2 more
Two patients with suspected cases of septic scarlet fever due to Streptococcus pyogenes Group A (serotype M1/T1/OF-) cellulitis in healthy young adults died despite prompt treatment.
The Journal of Infectious DiseasesRelationship of Acute Rheumatic Fever to Acute Glomerulonephritis in Trinidad
23 Citations1972E. V. Potter, Mauri Svartman +4 more
While streptococcal skin infections have been associated with acute glomerulonephritis, no such association has been apparent with rheumatic fever, and titers of antistreptolysin O were relatively low, while Titers of antihyaluronidase were markedly increased in the patients with acute rhematic fever.
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