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The amino acid sequence of the phosphorylation site of muscle uridine diphosphoglucose α-1,4-glucan α-4-glucosyl transferase

Journal of Molecular BiologyPublished 1 March 1965
Joseph Larner, Frederick Sanger
Citations67
SJR quartileQ1
SJR score2.21
SNIP1.13

TL;DR

The amino acid sequence at the site of phosphorylation of the enzyme uridine diphosphoglucose α-1,4-glucan α-4- glucosyl transferase in rat and rabbit muscle was studied with 32 P-labelled ATP using radiochemical techniques and was shown to be very similar to, or identical with, the sequence in rabbit muscle phosphoryl-ase a.

Abstract

The amino acid sequence at the site of phosphorylation of the enzyme uridine diphosphoglucose α-1,4-glucan α-4-glucosyl transferase in rat and rabbit muscle was studied with 32 P-labelled ATP using radiochemical techniques. The hexapeptide sequence was shown to be Arg Lys } − Glu − Ile − Ser ‐ P − Val − Arg . This is very similar to, or identical with, the sequence in rabbit muscle phosphoryl-ase a , suggesting that the two proteins are probably related.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology