Hu- <i>ets</i> -1 and Hu- <i>ets</i> -2 Genes Are Transposed in Acute Leukemias with (4;11) and (8;21) Translocations
SciencePublished 24 January 1986
Nicoletta Sacchi, Dennis K. Watson, Ad H. M. Guerts van Kessel, Anne Hagemeijer, John Kersey, Harry D. Drabkin
Citations187
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Two translocations of the human ets gene were found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell.
Abstract
Human probes identifying the cellular homologs of the v-ets gene, Hu-ets-1 and Hu-ets-2, and two panels of rodent-human cell hybrids were used to study specific translocations occurring in acute leukemias. The human ets-1 gene was found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell. Similarly, the human ets-2 gene was found to translocate from chromosome 21 to chromosome 8 in the t(8;21)(q22;q22), a nonrandom translocation commonly found in patients with acute myeloid leukemia with morphology M2 (AML-M2). Both translocations are associated with expression different from the expression in normal lymphoid cells of ets genes, raising the possibility that these genes play a role in the pathogenesis of these leukemias.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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