Formation and regional distribution of γ-hydroxybutyric acid in mammalian brain
Biochemical PharmacologyPublished 1 December 1970
Robert H. Roth
Citations88
SJR quartileQ1
SJR score1.60
SNIP1.24
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Abstract
Studies in vitro with rat brain cortical slices revealed that, similar to observations in vivo, γ-aminobutyric acid can serve as a precursor of γ-hydroxybutyric acid (GHB). Endogenous GHB had a discrete distribution in guinea pig brain with the highest concentration found in the hippocampus, midbrain and diencephalon and cerebellum. Subcellular investigations of sucrose homogenates of guinea pig brain demonstrated that very little GHB was found associated with the particulate fraction. Administration of ethanol, an agent known to alter tissue redox potentials, caused a marked increase in tissue levels of GHB, presumably by facilitating the reduction of succinic semialdehyde.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and Pharmaceutics
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