Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease).
Journal of Neurology Neurosurgery & PsychiatryPublished 1 December 1989Open access
T Révész, Philip N. Hawkins, E P du Boulay, Rita Barnard, W. I. McDonald
Citations83
SJR quartileQ1
SJR score3.38
SNIP2.41
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Formalin-fixed brain slices from four cases of subcortical arteriosclerotic encephalopathy in which a firm diagnosis could be made both clinically and pathologically have been studied by magnetic resonance imaging (MRI), finding a good correlation between the extent and severity of the abnormal MRI signal and the pathological changes.
Abstract
Formalin-fixed brain slices from four cases of subcortical arteriosclerotic encephalopathy in which a firm diagnosis could be made both clinically and pathologically have been studied by magnetic resonance imaging (MRI). The slices were subsequently embedded in paraffin-wax or celloidin and sections were cut in the same plane as the MRI slices. There was a good correlation between the extent and severity of the abnormal MRI signal and the pathological changes. Areas of diffuse MRI abnormality corresponded with areas of axonal and myelin loss with gliosis, and small "lacune"-like lesions corresponded with lacunar infarcts histologically. Sparing of the subcortical U-fibres was seen histologically and on MRI. The abnormal signal probably originates from increased tissue water attributable to gliosis and an expanded extracellular space.
Keywords
Materials ScienceNeuroscienceBiochemistry, Genetics and Molecular Biology
Archives of NeurologyLeuko-Araiosis
745 Citations1987V C Hachinski, P. Potter +1 more
It is argued that a neutral term, exact enough to define white-matter changes, sufficient as a description or label, and demanding enough to require precise clinical and imaging descriptions is needed.
BrainTHE ROLE OF NMR IMAGING IN THE ASSESSMENT OF MULTIPLE SCLEROSIS AND ISOLATED NEUROLOGICAL LESIONS
466 Citations1987I E Ormerod, David H. Miller +13 more
Evidence is adduced to support the view that an important source of the abnormal NMR signals in acute lesions is oedema, and in chronic lesions is gliosis; demyelination per se is unlikely to make an important contribution.
NeurologyClinical features of subcortical arteriosclerotic encephalopathy (Binswanger disease)
283 Citations1978Louis R. Caplan, William C. Schoene
The clinical picture in 11 patients was characterized by: persistent hypertension and systemic vascular disease; acute strokes; subacute accumulation of focal neurologic symptoms and signs over weeks to months; long plateau periods; and dementia.
RadiologyComparison of CT and MR in 400 patients with suspected disease of the brain and cervical spinal cord.
261 Citations1984W G Bradley, Victor Waluch +2 more
MR was superior to CT in detection of multiple sclerosis, subcortical arteriosclerotic encephalopathy, posterior fossa infarcts and tumors, small extra-axial fluid collections, and cervical syringomyelia and CT was preferable in evaluation of meningiomas and separation of tumor from edema.
Archives of NeurologySubcortical Arteriosclerotic Encephalopathy (Binswanger's Disease)
257 Citations1985William R. Kinkel
Elderly patients with subcortical arteriosclerotic encephalopathy may be a relatively common affliction of elderly patients, most of whom have risk factors for arteriosclerosis, and the modes of presentation and associated clinical signs are variable, and more than one third may have no neurologic deficit.
PubMedMR imaging of the aging brain: patchy white-matter lesions and dementia.
239 Citations1985Michael Brant‐Zawadzki, George Fein +4 more
NeurologyPathogenesis of Binswanger chronic progressive subcortical encephalopathy
164 Citations1980Jacques De Reuck, Luc Crevits +3 more
The clinicopathologic findings in four hypertensive patients with multiple leukomalacia, demyelinated lesions, and lacunar state suggest that Binswanger encephalopathy does not differ from multi-infarct dementia.
Journal of Neurology Neurosurgery & PsychiatrySubcortical arteriosclerotic encephalopathy: a clinical and radiological investigation.
139 Citations1981L A Loizou, B. E. Kendall +1 more
Subcortical arteriosclerotic encephalopathy (Binswanger's type) was diagnosed in a group of patients with hypertension or arteriosclerosis, who showed acute and subacute neurological deficits, dementia, reduced cerebral blood flow, and white matter low attenuation with mild atrophy and infarcts as the predominant CT scan features.
NeurologyMagnetic resonance imaging in vascular dementia
106 Citations1987Linda A. Hershey, Michael T. Modic +2 more
Patients with vascular dementia show distinctive white matter lesions on MRI, and enlargement of central CSF spaces was the only radiographic feature that was seen more commonly in demented than in nondemented patients with ischemic cerebrovascular disease.
Journal of Computer Assisted TomographyPredominant White Matter Involvement in Subcortical Arteriosclerotic Encephalopathy (Binswanger Disease)
106 Citations1980H. Zeumer, B. Schonsky +1 more
A diagnosis of encephalopathia subcorticalis chronica progressiva, or Binswanger disease, featuring the typical clinical course of neurological and psychiatric symptoms was reached in one case, confirmed by postmortem anatomopathological findings.
BrainTHE CHARACTERIZATION OF EXPERIMENTAL GLIOSIS BY QUANTITATIVE NUCLEAR MAGNETIC RESONANCE IMAGING
99 Citations1988David Barnes, W. I. McDonald +2 more
The pattern of change of the relaxation times and T2 magnetization decay might provide a means of distinguishing between lesions in multiple sclerosis which are predominantly gliotic, and those containing significant amounts of oedema.
Journal of Neurology Neurosurgery & PsychiatryCorpus callosum in multiple sclerosis
97 Citations1974Rita Barnard, Margaret Triggs
The ventricular enlargement noted in this series could not be explained either on the basis of obstruction to the flow of cerebrospinal fluid, or by the effects of shrinkage of the white matter.
NeuroradiologySTIR sequences in NMR imaging of the optic nerve
79 Citations1987Glyn Johnson, David H. Miller +5 more
Subcortical Arteriosclerotic Encephalopathy
79 Citations1989Jacob Valk, Marjo S. van der Knaap
SAE is a relatively common affliction of elderly patients, most of whom have risk factors for arteriosclerosis, although there are also reports of patients whose necropsy examinations reveal SAE but who did not have hypertension during life.
Journal of the Neurological SciencesFormalin fixed brains are useful for magnetic resonance imaging (MRI) study
78 Citations1987Hitoshi Nagara, T. Inoue +4 more
The demyelinated lesions of the fixed brains in cases of multiple sclerosis, progressive multifocal leukoencephalopathy, and Balo's concentric sclerosis definitely re-appeared, although T1 and T2 in the gray and white matter were reduced following fixation.
European Archives of Psychiatry and Clinical NeuroscienceProgressive subcorticale vascul�re Encephalopathie Binswanger
75 Citations1964K. A. Jellinger, E Neumayer
Psychological MedicineDementia, deep white matter damage and hypertension: ‘Binswanger's disease’
71 Citations1981I. Janota
The clinical and neuropathological features are reported of 7 patients with organic intellectual impairment or dementia, hypertension and ischaemic destruction predominantly of the deep white matter of the cerebral hemispheres resembling that seen in infarction.
StrokeNMR-neuropathologic correlation in stroke.
59 Citations1987L. Dana DeWitt, J. Philip Kistler +3 more
True, three-dimensional proton nuclear magnetic resonance imaging at 0.147 tesla was performed postmortem on 2 patients embodying various stroke syndromes, including chronic (4 and 15 years) infarction, subacute (within 1 week) bland infarctions, acute (2 days) hemorrhagic infarition, and hematoma secondary to ruptured aneurysm.
Acta Neurologica ScandinavicaSubcortical arteriosclerotic encephalopathy (Binswanger's disease): a report of five patients
16 Citations1987E García-Albea, A Cabello +1 more
Five patients with variable clinical symptoms were diagnosed as having—subcortical arteriosclerotic encephalopathy (Binswanger disease) based on the presence of lacunar infarcts in basal ganglia, various abnormalities of sub cortical white matter and severe thickening and hyalinization of penetrating arteries and arterioles.