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Phenytoin as an Antimanic Anticonvulsant: A Controlled Study

American Journal of PsychiatryPublished 1 March 2000
Alexander Mishory, Yuri Yaroslavsky, Yuly Bersudsky, Robert H. Belmaker
Citations117
SJR quartileQ1
SJR score5.27
SNIP3.68

TL;DR

Significantly more improvement was observed in the patients receiving phenytoin and blockade of voltage-activated sodium channels may be a common therapeutic mechanism of many anticonvulsants given for mania, and pheny toin may beA therapeutic option for some manic patients.

Abstract

Blockade of voltage-activated sodium channels may be a common therapeutic mechanism of many anticonvulsants given for mania, and phenytoin may be a therapeutic option for some manic patients.

Keywords

Medicine