Molecular cloning of a cDNA encoding human antihaemophilic factor
NaturePublished 1 November 1984
John J. Toole, John L. Knopf, John M. Wozney, Lisa A. Sultzman, Janet L. Buecker, Debra D. Pittman
Citations938
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed and has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
Abstract
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
Keywords
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