14-3-3 protein ? chain gene (YWHAH) polymorphism and its genetic association with schizophrenia
American Journal of Medical GeneticsPublished 16 April 1999
Kazuhiko Toyooka, Tatsuyuki Muratake, Toshihisa Tanaka, Shuichi Igarashi, Hiromi Watanabe, Hiromori Takeuchi
Citations70
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TL;DR
The 14-3-3 eta chain gene, abundant in the brain, mediates interactions between diverse molecules of biological activities and is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia.
Abstract
Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12-q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1-q13.1. We therefore investigated allele frequencies of a variable number of tandem repeat (VNTR) in the 5'-noncoding region of the 14-3-3 eta chain gene in controls and schizophrenics. The frequencies of the two-repeat allele were significantly higher (P < 0.05) in the schizophrenics, and particularly in those with onset before age 22 (early-onset schizophrenics, P < 0.02), than in the controls. The odds ratio was significantly increased in the early-onset schizophrenics homozygous for the two-repeat allele (OR = 3.3, 95% CI = 1.1-9.7). The 14-3-3 eta chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia.
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology
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