An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).
The Journal of Experimental MedicinePublished 1 January 1990Open access
Scott R. Burrows, T B Sculley, I S Misko, Christopher Schmidt, Denis J. Moss
Citations173
SJR quartileQ1
SJR score5.83
SNIP1.99
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TL;DR
This report is the first description of an EBV target epitope recognized by specific CTL clone, and one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells.
Abstract
Epstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). This report is the first description of an EBV target epitope recognized by specific CTL clones.
Keywords
Immunology and MicrobiologyMedicine
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