A family of cyclin homologs that control the G1 phase in yeast.
Proceedings of the National Academy of SciencesPublished 1 August 1989Open access
Jeffrey A. Hadwiger, Curt Wittenberg, Helena E. Richardson, Miguel de Barros Lopes, Steven I. Reed
Citations419
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TL;DR
Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division.
Abstract
Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.
Keywords
Biochemistry, Genetics and Molecular Biology
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