Histochemical detection of apoptosis in Parkinson's disease
Journal of the Neurological SciencesPublished 1 May 1996
Hideki Mochizuki, Keigo Goto, Hideo Mori, Yoshikuni Mizuno
Citations448
SJR quartileQ1
SJR score1.15
SNIP0.99
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TL;DR
Evidence to indicate apoptosis in the substantia nigra of Parkinson's disease patients is reported and intense nuclear staining indicating apoptotic process was observed in 8 out of 11 parkinsonian patients studied.
Abstract
Apoptosis may be an important mechanism of cell death in some experimental disease models as well as in human neurodegenerative disorders. We report evidence to indicate apoptosis in the substantia nigra of Parkinson's disease patients. We studied the midbrains of 7 patients with late onset PD, 4 patients with young onset PD and 6 control subjects using the nick-end labeling method. Intense nuclear staining indicating apoptotic process was observed in 8 out of 11 parkinsonian patients studied. Apoptosis may be a contributor to the nigral neuronal death in Parkinson's disease (PD).
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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