Transfer of specificity by murine α and β T-cell receptor genes
NaturePublished 1 March 1986
Zlatko Dembić, Werner Haas, Siegfried Weiß, James A. McCubrey, Hansruedi Kiefer, Harald von Boehmer
Citations575
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
T-cell receptor α- and β-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T- cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity.
Abstract
T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.
Keywords
Immunology and MicrobiologyMedicine
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