Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
CellPublished 1 February 1995Open access
Ping Li, Hamish Allen, Subhashis Banerjee, Simon Franklin, Linda Herzog, Cynthia G. Johnston
Citations1,415
SJR quartileQ1
SJR score22.61
SNIP7.62
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TL;DR
IL-1β-converting enzyme (ICE) plays a dominant role in the generation of mature IL- 1β, a previously unsuspected role in production of IL-1α, but has no autonomous function in apoptosis.
Abstract
IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/lch-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1 beta after stimulation with lipopolysaccharide. IL-1 alpha production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1 beta, a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis.
Keywords
Immunology and MicrobiologyMedicineBiochemistry, Genetics and Molecular Biology
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