Pulmonary Talc Granulomas, Pulmonary Fibrosis, and Pulmonary Hypertension Resulting from Intravenous Injection of Talc-Containing Drugs Intended for Oral Use
Baylor University Medical Center ProceedingsPublished 1 July 2002Open access
William C. Roberts
Citations45
SJR quartileQ3
SJR score0.26
SNIP0.37
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Talcosis or talc pneumoconiosis is an uncommon form of pulmonary dust disease first recognized over 100 years ago and, if inhaled in large amounts, dries the tracheobronchial mucous membrane and prevents normal ciliary function.
Abstract
"Pulmonary Talc Granulomas, Pulmonary Fibrosis, and Pulmonary Hypertension Resulting from Intravenous Injection of Talc-Containing Drugs Intended for Oral Use." Baylor University Medical Center Proceedings, 15(3), pp. 260–261
Keywords
Medicine
The American Journal of MedicineIntravenous injection of talc-containing drugs intended for oral use
128 Citations1976Ernest N. Arnett, William E. Battle +2 more
It is clear, however, that severe pulmonary hypertension may be a consequence of intravenous injection of drugs intended for oral use, as demonstrated by one of the authors' patients.
American Review of Respiratory DiseaseLong-term Follow-up of Drug Abusers with Intravenous Talcosis
125 Citations1989Joshua Paré, Gilles Côté +1 more
Six patients who injected talc containing drugs intended for oral use were assessed over a period of ten or more years from the time of initiation of this habit, all developed severe respiratory disability and three died from their disease.
MedicinePulmonary ‘Mainlineʼ Granulomatosis
111 Citations1979J. A. PETER PARÉ, Robert Fraser +3 more
The one patient who died revealed severe pulmonary fibrosis and talc granulomas in lungs, liver, kidneys and lymph nodes, and Corticosteroid therapy was attempted on two and was ineffective.
American Review of Respiratory DiseasePanlobular Emphysema in Young Intravenous Ritalin® Abusers
80 Citations1991Rodney A. Schmidt, Robb W. Glenny +4 more
It is indicated that some intravenous drug abusers develop emphysema that clinically, radiologically, and pathologically resembles that caused by alpha-1-antitrypsin deficiency but which must have a different pathogenesis.
PubMedTalc granulomatosis: laboratory findings similar to sarcoidosis.
52 Citations1982Harrison W. Farber, R. Paul Fairman +1 more
It is concluded that talc granulomatosis can mimic the laboratory findings of pulmonary sarcoidosis, but the findings of birefringent particles in the bronchoalveolar lavage fluid by polarized microscopy is a simple laboratory method for confirming a clinical diagnosis.
The American Journal of MedicineTalc pneumoconiosis
45 Citations1971Albert Miller, Alvin S. Teirstein +3 more
The significance of submicroscopic talc particles in the production of disease is demonstrated and related to similar findings in asbestosis.
Archives of Environmental Health An International JournalStudies of Respiratory Morbidity in Rubber Workers
37 Citations1976Lawrence J. Fine, John Peters +2 more
A safe exposure level for talc appears to be 25 mg/m3 as a time-weighted average, based on this study, and talc workers had a clear increase in respiratory morbidity, despite the absence of chest roentgenographic changes.
New England Journal of MedicineFatal Aspiration of Talcum Powder by a Child
23 Citations1962John J. Molnar, Gerald Nathenson +1 more
The case reported below demonstrates a rapidly fatal course in a twenty-two-month-old child, who aspirated talcum powder while playing with such a container.
CHEST JournalTalc Granulomatosis
16 Citations2000Daniel Nan, Marta Fernández‐Ayala +4 more
Consumers of adulterated drugs may present with talc-induced interstitial lung disease, and a transbronchial biopsy specimen showing granulomas with intracellular talc crystals is necessary to confirm this diagnosis.