EFFECT OF GROWTH HORMONE ON PLASMA FATTY ACIDS*
Journal of Clinical InvestigationPublished 1 March 1959Open access
M. S. Raben, C. H. Hollenberg
Citations450
SJR quartileQ1
SJR score4.72
SNIP2.17
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Abstract
Administration of growth hormone to animals has been found to reduce fat stores (1, 2), to increase liver fat (3,4) and to cause ketosis (5) and a de- pression of respiratory quotient (6, 7).The in- crease in mobilization and metabolism of fat im- plied by these findings has been thought to con- tribute either in an auxiliary or in an essential way to the anabolic stimulus induced by growth hor- mone.
Keywords
MedicineAgricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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The data reported in the present publication were obtained by a procedure which has the advantage of high specificity, although it is appreciably more laborious than the method of Dole.
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Fatty livers produced in rats by fasting, by diets rich in fat, cholesterol feeding, phosphorus poisoning, and by diets deficient in choline and in other " lipotropic " factors have been recently studied in laboratories, but the rate of accumulation of fat in the liver when large doses of the anterior pituitary extract are given is greater than that caused by any of these other procedures.
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Extraction of acetone-dried hog anterior pituitary glands with glacial acetic acid at 70 °C and removal of corticotropin with oxycellulose provides a method for the preparation of cortingotropin and growth hormone in a single procedure.
