Ondansetron in the Prophylaxis of Postoperative Vomiting: A Meta-analysis
Journal of Clinical AnesthesiaPublished 1 May 1998
E Figueredo, Liliana G. Canosa
Citations72
SJR quartileQ1
SJR score1.33
SNIP1.98
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TL;DR
While ondansetron is an effective antiemetic with minimal adverse effects, the data obtained on the numbers needed to be treated calculation for prophylaxis of postoperative vomiting should be considered in future cost-effective strategies of postoperatively management.
Abstract
While ondansetron is an effective antiemetic with minimal adverse effects, the data obtained on the numbers needed to be treated calculation for prophylaxis of postoperative vomiting should be considered in future cost-effective strategies of postoperative management.
Keywords
Medicine
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23 Citations1997William M. Splinter, Elliot J. Rhine
150 μg·kg−1 ondansetron is a more effective prophylactic antiemetic among children undergoing elective tonsillectomy among preadolescent children in a day care surgical setting.
Anaesthesia and Intensive CareThe Prophylactic Antiemetic Efficacy of Prochlorperazine and Ondansetron in Nasal Septal Surgery: A Randomized Double-Blind Comparison
22 Citations1996Anton Berg
It is concluded that these drugs have no adverse cardiovascular effects within 10 minutes of administration, and reduce PONV more effectively than i.m. prochlorperazine and i.v. ondansetron.
PubMedOral ondansetron in the prevention of postoperative nausea and vomiting.
21 Citations1992J. H. J. H. Helmers
8 mg three times daily is recommended as the optimal oral dose in the prevention of postoperative nausea and vomiting in female patients about to undergo major abdominal gynaecological surgery or vaginal hysterectomy.
Der AnaesthesistIntraven�se Gabe von Ondansetron vs. Metoclopramid zur Prophylaxe von postoperativer �belkeit und Erbrechen
19 Citations1995Meinhard Rust
In the ondansetron group the total number of emetic episodes, the median time to the first emetic episode or treatment failure, and the duration and severity of nausea were reduced significantly compared with metoclopramide or placebo.
Journal of Oral and Maxillofacial SurgeryThe effect of a 4-Mg preoperative intravenous dose of ondansetron in preventing nausea and vomiting after maxillofacial surgery
18 Citations1996Chandra Rodrigo, Robert C. Campbell +2 more
Four milligrams ondansetron given intravenously preoperatively was ineffective in controlling postoperative nausea and vomiting after maxillofacial surgery, and a larger dose or a second dose given 8 hours after the first dose may be effective.
British Journal of AnaesthesiaComparison of ondansetron and prochlorperazine for the prevention of nausea and vomiting after adenotonsillectomy
17 Citations1996Anton Berg
This study has compared the incidences of nausea, vomiting and headache after ondansetron 0.06 mg kg-1 i.v. given during induction of general anaesthesia to 282 patients undergoing adenotonsillectomy.
Anesthesia & AnalgesiaComparison of Ondansetron and Droperidol in the Prevention of Nausea and Vomiting After Inpatient Minor Gynecologic Surgery
17 Citations1995Stefan Grond, John Lynch +3 more
Der AnaesthesistOndansetron als Prophylaxe f�r postoperative �belkeit und Erbrechen
17 Citations1994Eli Alon, Péter Bíró +2 more
PubMedClinical evaluation of different doses of pipecuronium bromide during nitrous-oxide-fentanyl anaesthesia in adult surgical patients.
15 Citations1992M Sanfilippo, G. Fierro +4 more
The neuromuscular and cardiovascular effects of three different doses of pipecuronium were studied in 60 adult patients and recovery indices were measured in all patients after neostigmine and edrophonium administration.
PubMedExperience with ondansetron in chemotherapy- and radiotherapy-induced emesis.
13 Citations1992Mario Dicato, Andrew Freeman
Ondansetron was found to be superior to metoclopramide in the control of nausea and emesis over the first 24 h following treatment, when these side-effects are normally most severe.
Annales Françaises d Anesthésie et de RéanimationPrévention des nausées et vomissements postopératoires par l'ondansétron
12 Citations1992A. Bouly, N. Nathan +1 more
It is concluded that oral ondansetron, 8 mg taken orally 1 h before surgery, significantly reduces the incidence of nausea and vomiting during the first twelve postoperative hours.
PubMedMethodology and assessment in clinical anti-emetic research: a meta-analysis of outcome parameters.
12 Citations1992Gary R. Morrow
Examination of 153 separate anti-emetic studies between the years of 1975 and 1988 showed that emesis was the most common outcome measure used and that approximately 1 out of five studies measured some other type of outcome usually in the context of nausea and emesis.
OphthalmologicaProphylactic Intravenous Ondansetron in Patients Undergoing Cataract Extraction under General Anesthesia
11 Citations2010Francisco J. Ascaso, Ignacio Ayala +3 more
This is the first study to demonstrate that ondansetron is effective to prevent postoperative emesis after extracapsular cataract extraction and the incidence of postoperative nausea was significantly less in the ondANSetron group than that in the metoclopramide group.
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