Elimination of circadian rhythms in drinking, activity, sleep, and temperature by isolation of the suprachiasmatic nuclei
Behavioral BiologyPublished 1 May 1977
Friedrich K. Stephan, Antonio A. Núñez
Citations173
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TL;DR
The results support the hypothesis that the suprachiasmatic nuclei may serve as a central neural pacemaker responsible for the generation and entrainment of a number of circadian rhythms in physiology and behavior, and that the regulation of rhythmic functions is mediated by neural efferents from the su PRS nuclei.
Abstract
Isolation or destruction of the suprachiasmatic nuclei of rats resulted in an immediate and apparently permanent elimination of circadian rhythms in drinking, wheel running, slow wave sleep, cortical arousal, and brain temperature. While activity levels were reduced, total daily water intakes and amounts of sleep and arousal were not substantially affected. Paradoxical sleep was arhythmic in some animals, whereas others showed a predominantly nocturnal pattern following the lesions. The results support the hypothesis that the suprachiasmatic nuclei may serve as a central neural pacemaker responsible for the generation and entrainment of a number of circadian rhythms in physiology and behavior, and that the regulation of rhythmic functions is mediated by neural efferents from the suprachiasmatic nuclei.
Keywords
PsychologyNeuroscience
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