Transcription activation by the adenovirus E1a protein
NaturePublished 1 March 1989
James W. Lillie, Michael R. Green
Citations667
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
It is shown that Ela has the two functions characteristic of a typical cellular activator: one direct Ela to the promoter, perhaps by interacting with a DMA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.
Abstract
The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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