A maximum confidence strategy for measuring progression and regression of coronary artery disease in clinical trials
Developments in cardiovascular medicinePublished 1 January 1993
B. Greg Brown, Lynn A. Hillger, Xue-Qiao Zhao, Dianne Sacco, Brad Bisson, Lloyd D. Fisher
Citations18
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TL;DR
Two different arteriographic approaches were compared in a clinical trial, and the degree of concordance between disease change measured by these two approaches and clinical outcomes was assessed, leading to excellent agreement between these two fundamentally different methods of disease change assessment.
Abstract
The excellent agreement between these two fundamentally different methods of disease change assessment and the concordance between disease change and clinical outcomes greatly strengthens confidence both in these measurement techniques and in the overall findings of the study. These observations have important implications for the design of clinical trials with arteriographic end points.
Keywords
Medicine
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