Role of alpha1 Acid Glycoprotein in the In Vivo Resistance of Human BCR-ABL+ Leukemic Cells to the Abl Inhibitor STI571
JNCI Journal of the National Cancer InstitutePublished 18 October 2000Open access
Carlo Gambacorti‐Passerini
Citations322
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Abstract
AGP in the plasma of relapsed animals binds to STI571, preventing this compound from inhibiting the Bcr/Abl tyrosine kinase. Molecules such as erythromycin that compete with STI571 for binding to AGP may enhance the therapeutic potential of this drug.
Keywords
Medicine
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