Metabolic Mapping of the Brain During Rewarding Self-Stimulation

SciencePublished 20 April 1984

Linda J. Porrino, Ralph Esposito, Thomas Seeger, Alison M. Crane, Agu Pert, Louis Sokoloff

DOI10.1126/science.6710145

Source URL

Citations122

SJR quartileQ1

SJR score10.42

SNIP6.62

TL;DR

Rats trained in intracranial self-stimulation showed a pattern of changes in forebrain metabolic activity distinctly different from the pattern seen in rats stimulated by the experimenter.

Abstract

Local rates of cerebral glucose utilization were measured in rats by the quantitative 2-deoxy-D-[14C]glucose autoradiographic method during electrical stimulation of the ventral tegmental area. Rats trained in intracranial self-stimulation showed a pattern of changes in forebrain metabolic activity distinctly different from the pattern seen in rats stimulated by the experimenter. These findings provide information about the distribution of local cerebral activity specific to reinforced instrumental behavior.

Keywords

MedicineNeuroscience

UA Campus Repository (The University of Arizona)The Hippocampus as a Cognitive Map

7,925 Citations1978John O’Keefe, Lynn Nadel

The amnesic syndrome is an extension of the theory to humans and an extension of the theory to humans to animals and humans.

View PDF

Journal of NeurochemistryTHE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1

6,025 Citations1977Louis Sokoloff, Martin Reivich +6 more

The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.

Springer series in statisticsSimultaneous Statistical Inference

5,637 Citations1981Rupert G. Miller

View PDF

Annals of NeurologyComputerized densitometry and color coding of [14C] deoxyglucose autoradiographs

343 Citations1980Charles F. Goochee, Wayne Rasband +1 more

It is possible to generate quantitative metabolic maps that display the distribution of actual rates of local glucose utilization throughout the entire central nervous system in regions as small as 100 μm or less.

ScienceEscape from Self-Produced Rates of Brain Stimulation

100 Citations1969Solomon S. Steiner, Bernard Beer +1 more

Rats were allowed to self-stimulate while their responses were being recorded on tape and then prerecorded patterns of their brain stimulation were "played back" to them.

The Journal of Comparative NeurologyRegional (14C) 2‐deoxyglucos uptake during vibrissae movements evoked by rat motor cortex stimulation

73 Citations1982Frank R. Sharp, Kathleen Evans

Regional increases of (14C) 2‐deoxyglucose (2DG) uptake were mapped autoradiographically duringetitive left mystacial vibrissae movements produced by electrical stimulation of right motor cortex (MI) with a bipolar electrode in the alert, unanesthetized rat.

PubMedThe amygdala: historical and functional analysis.

69 Citations1973Richardson Js

An intact amygdala seems to be essential for the successful performance of behavior patterns such as instinctive food getting and instinctive defensive reactions that are necessary for the survival of the individual organism and the species.

Proceedings of the National Academy of SciencesChanges in local cerebral glucose utilization during rewarding brain stimulation.

42 Citations1984Ralph Esposito, Linda J. Porrino +4 more

The results indicate that rather than a diffuse pattern of activity, rewarding brain stimulation is associated with discrete activation of specific neuronal projection fibers and selective terminal sites.

View PDF

Experimental NeurologyFunctional metabolic mapping of a conditioned motor task in primates utilizing 2-[14C]deoxyglucose

27 Citations1981Robert J. Schwartzman, Joel Greenberg +3 more

The value of the quantitative 2DG technique is demonstrated in the study of functional neuroanatomic relationships during an operantly conditioned paradigm of Macacca mulatta monkeys.