Correlation Between the Binding Properties and Pharmacological Responses of Muscarinic Receptors
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TL;DR
With the development of methods of measuring directly the binding of drugs to muscarinic receptors, an independent set of data has been obtained which should permit a more detailed understanding of the nature ofMuscarinic drug action.
Abstract
Until recently our understanding of the nature of how muscarinic drugs act on tissues has been derived from an analysis of the actions of agonists and antagonists on some physiological response such as the contraction of smooth muscle. With the development of methods of measuring directly the binding of drugs to muscarinic receptors, an independent set of data has been obtained which should permit a more detailed understanding of the nature of muscarinic drug action.