α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function
Biological PsychiatryPublished 1 January 1999
Amy F.T. Arnsten, Rex G. Mathew, Ravi Ubriani, Jane R. Taylor, Bao‐Ming Li
Citations241
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SJR score4.68
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TL;DR
These findings demonstrate that alpha-1 adrenoceptor stimulation in the PFC impairs cognitive function, and may contribute to PFC deficits in disorders such as mania, dementia, and anxiety associated with high noradrenergic turnover.
Abstract
These findings demonstrate that alpha-1 adrenoceptor stimulation in the PFC impairs cognitive function. Excessive stimulation of alpha-1 adrenoceptors may contribute to PFC deficits (e.g., distractibility, impulsivity) in disorders such as mania, dementia, and anxiety associated with high noradrenergic turnover.
Keywords
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