Association between clozapine response and allelic variation in 5-HT2A receptor gene
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TL;DR
Evidence is found that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.
Abstract
We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.