High-affinity fluorescent ligands for the 5-HT3 receptor
Bioorganic & Medicinal Chemistry LettersPublished 7 December 2011Open access
Jonathan Simonin, Sanjeev Kumar V. Vernekar, Andrew J. Thompson, Joanne Hothersall, Christopher N. Connolly, Sarah C. R. Lummis
Citations21
SJR quartileQ2
SJR score0.47
SNIP0.60
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Abstract
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.
Keywords
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