Influence of various psychoactive drugs on the in vivo metabolism of d-Amphetamine in the rat
European Journal of PharmacologyPublished 1 April 1969
Tommy Lewander
Citations58
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
D-amphetamine-3H was injected i.p. to rats, pretreated with different drugs and the pattern of labeled metabolites of amphetamine in the urine was determined, demonstrating an increase in the excretion of unchanged amphetamine and a decrease in urinary p-OH-amphetamine.
Abstract
D-amphetamine-3H was injected i.p. to rats, pretreated with different drugs and the pattern of labeled metabolites of amphetamine in the urine was determined. Desmethylimipramine dose-dependently inhibited the p-hydroxylation of amphetamine, which was demonstrated by an increase in the excretion of unchanged amphetamine and a decrease in urinary p-OH-amphetamine. Other drugs found to inhibit p-hydroxylation of amphetamine were: imipramine, nortriptyline, protriptyline, Lu 3-010 (ftalan-derivative), chlorpromazine, promethazine, chlorprothixene, prochlorperazine, chlordiazepoxide, diazepam, nialamide and cocaine. The following drugs were without effect on amphetamine hydroxylation: haloperidol, meprobamate, secobarbital, reserpine and atropine. Repeated injections of phenobarbital accelerated the formation of p-OH-amphetamine.
Keywords
MedicineNeuroscience
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