Histological evidence for adulticidal effect of low doses of diethylcarbamazine in bancroftian filariasis
Transactions of the Royal Society of Tropical Medicine and HygienePublished 1 March 1996
José Figueredo‐Silva, Patrícia Jungmann, Joaquim Norões, Willy F. Piessens, Amaury Coutinho, Carlos Alexandre Antunes de Brito
Citations51
SJR quartileQ2
SJR score0.64
SNIP0.77
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TL;DR
The ability of diethylcarbamazine (DEC) to kill adult Wuchereria bancrofti worms was evaluated by examining lymphatic nodules formed after treatment with 4 different treatment schedules of 193 males living in the endemic area of Greater Recife, Brazil.
Abstract
The ability of diethylcarbamazine (DEC) to kill adult Wuchereria bancrofti worms was evaluated by examining lymphatic nodules formed after treatment with 4 different treatment schedules of 193 males living in the endemic area of Greater Recife, Brazil. Lymphatic nodules appeared in the spermatic cord or upper extremities in 43 of 138 microfilaraemic individuals, in 3 of 30 amicrofilaraemic patients with filarial disease manifestations, and in 1 of 25 asymptomatic amicrofilaraemic residents of the endemic area treated with DEC. Fourteen of these nodules were surgically removed 10-150 d after the start of treatment. Regardless of the DEC dosage and schedule used, all nodules contained damaged and degenerating adult worms. An exuberant granulomatous process with large numbers of eosinophils and progressive fibrosis gradually developed around the dead parasites. The mechanism(s) by which DEC killed adult W. bancrofti could not be determined.
Keywords
MedicineEnvironmental Science
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