Misoprostol for the Treatment of Peptic Ulcer and Antiinflammatory-Drug–Induced Gastroduodenal Ulceration
New England Journal of MedicinePublished 26 November 1992
Alastair J.J. Wood, Robert P. Walt
Citations140
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
The use of the drug misoprostol in clinical practice is reviewed, with critical appraisal of its role in the prevention and management of upper gastrointestinal ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs).
Abstract
MISOPROSTOL was the first analogue of prostaglandin E1 to be commercially available. It was developed after prostaglandins of the E series had been found to inhibit the secretion of acid and prevent gastric injury caused by various substances, with the hope that it would be useful for the prevention and treatment of gastrointestinal ulceration. The aim of this article is to review the use of the drug in clinical practice, with critical appraisal of its role in the prevention and management of upper gastrointestinal ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs). In the United Kingdom, misoprostol . . .
Keywords
Medicine
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