Influence of emulsified fat on chlorpromazine availability in rabbit blood
Cellular and Molecular Life SciencesPublished 1 August 1974
Josef Krieglstein, A. Meffert, D. H. Niemeyer
Citations68
SJR quartileQ1
SJR score2.30
SNIP1.48
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TL;DR
Es konnte in vitro gezeigt werden, dass der Zusatz einer Fettemulsion zu Kaninchenblut (25 mg Fett/ml) den Anteil an freiem Chlorpromazin (Gesamtkonzentration 10−4 M) von 2,05% auf 0,87% herabsetzt.
Abstract
Kaninchen überlebten die letale Dosis von 30 mg/kg Chlorpromazin (i.v.) nur zusammen mit einer Fettinfusion (0,5 ml/kg/min Lipofundin S 10®). Es konnte in vitro gezeigt werden, dass der Zusatz einer Fettemulsion (Lipofundin S 10®) zu Kaninchenblut (25 mg Fett/ml) den Anteil an freiem Chlorpromazin (Gesamtkonzentration 10−4 M) von 2,05% auf 0,87% herabsetzt.
Keywords
Medicine
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