Effects of GABAergic Drugs In Vivo on High‐Affinity Choline Uptake In Vitro in Mouse Hippocampal Synaptosomes
Journal of NeurochemistryPublished 1 December 1986
Jerry A. Miller, J Richter
Citations17
SJR quartileQ1
SJR score1.50
SNIP1.02
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TL;DR
It appears that GABA mediates a tonic inhibitory effect on the septal‐hippocampal cholinergic system.
Abstract
The effects of several gamma-aminobutyric acid (GABA)-ergic drugs on sodium-dependent high-affinity choline uptake (HACU) were investigated in the hippocampus. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by those drugs that enhance GABA transmission. The convulsant 3-mercaptopropionic acid, which decreases GABA levels, stimulated HACU. From these results and previous findings, it appears that GABA mediates a tonic inhibitory effect on the septal-hippocampal cholinergic system.
Keywords
MedicineAgricultural and Biological SciencesNeuroscience
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