Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools
ThoraxPublished 1 August 1999Open access
Richard Sporik, Susan Pollart Squillace, Jim Mark Ingram, Gary P. Rakes, Richard W. Honsinger, Thomas A.E. Platts‐Mills
Citations227
SJR quartileQ1
SJR score2.45
SNIP2.08
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The domestic reservoir concentration of mite and cockroach, but not cat, allergen was closely related to the prevalence of sensitisation in atopic children, suggesting that other factors play a major part in determining which allergic individuals develop asthma.
Abstract
The domestic reservoir concentration of mite and cockroach, but not cat, allergen was closely related to the prevalence of sensitisation in atopic children. However, the prevalence of current asthma had a limited relationship to these allergen measurements, suggesting that other factors play a major part in determining which allergic individuals develop asthma.
Keywords
Medicine
New England Journal of MedicineAssociation of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens
1,668 Citations1989B BURROWS, Fernando D. Martínez +3 more
It is concluded that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens the authors used to assess atopic status.
New England Journal of MedicineExposure to House-Dust Mite Allergen (<i>Der p</i>I) and the Development of Asthma in Childhood
1,664 Citations1990Richard Sporik, Stephen T. Holgate +2 more
In addition to genetic factors, exposure in early childhood to house-dust mite allergens is an important determinant of the subsequent development of asthma.
New England Journal of MedicineThe Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with Asthma
1,375 Citations1997David L. Rosenstreich, Peyton A. Eggleston +9 more
The combination of cockroach allergy and exposure to high levels of this allergen may help explain the frequency of asthma-related health problems in inner-city children.
New England Journal of MedicineRelation between Airway Responsiveness and Serum IgE in Children with Asthma and in Apparently Normal Children
797 Citations1991M.R. Sears, Benjamin Burrows +4 more
Even in children who have been asymptomatic throughout their lives and have no history of atopic disease, airway hyperresponsiveness appears to be closely linked to an allergic diathesis, as reflected by the serum total IgE level.
New England Journal of MedicineGenetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy
763 Citations1995Dirkje S. Postma, Eugene R. Bleecker +6 more
ThoraxRapid method for measurement of bronchial responsiveness.
756 Citations1983K Yan, Cheryl M. Salome +1 more
The reproducibility of the PD20-FEV1, determined from duplicate measurements in 15 subjects with varying degrees of bronchial responsiveness was found to be satisfactory and the dose delivered by this method was shown to be cumulative.
Journal of Allergy and Clinical ImmunologyIndoor allergens and asthma:Report of the Third International Workshop
729 Citations1997Thomas A.E. Platts‐Mills, D. Vervloët +3 more
The Third International Workshop on Indoor Allergens and Asthma was designed to discuss recent progress in basic and clinical research in this area, to formulate recommendations for allergen-specific management of asthma, and to consider future research directions.
The LancetLINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q
618 Citations1989WilliamO.C.M. Cookson, JenniferA. Faux +2 more
Molecular genetic linkage analysis was used to confirm the transmission of atopy was linked, with a maximum lod score of 5.58, to a DNA polymorphism defined by p lambda MS, which confirms dominant inheritance and assigns the gene locus to chromosome 11.
Clinical & Experimental AllergyThe relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma
605 Citations1989Malcolm R. Sears, Peter Herbison +4 more
Allergen‐specific relative risk analysis demonstrated that sensitivity to house dust mite and to cat dander were highly significant independent risk factors associated with the development of asthma (whether defined as recurrent typical respiratory symptoms, increased airway responsiveness, or the concurrent presence of both).
Journal of Allergy and Clinical ImmunologyIndoor allergen exposure is a risk factor for sensitization during the first three years of life
524 Citations1997Ulrich Wahn, Susanne Lau +6 more
The data indicate that avoidance measures in the domestic environment aimed at the primary prevention of allergen-driven sensitization should be introduced at the earliest possible stage, if possible during infancy.
The LancetEffect of allergen avoidance on development of allergic disorders in infancy
520 Citations1992Syed Hasan Arshad, S. Matthews +2 more
American Journal of Respiratory and Critical Care MedicineHouse Dust Mite Allergens. A Major Risk Factor for Childhood Asthma in Australia
495 Citations1996Jennifer Peat, Euan R. Tovey +5 more
The data suggest that house dust mite allergens are an important cause of childhood asthma and that reducing exposure to these allergens could have a large public health benefit in terms of asthma prevention.
American Review of Respiratory DiseaseSensitization and Exposure to Indoor Allergens as Risk Factors for Asthma among Patients Presenting to Hospital
481 Citations1993Lawrence E. Gelber, Leonard H. Seltzer +4 more
There was a strong inverse relationship between IgE antibodies to cat and to cockroach, and the risk of this sensitization was in large part restricted to homes or areas with high levels of allergen.
American Review of Respiratory DiseaseAnalysis of Dose-Response Curves to Methacholine: An Approach Suitable for Population Studies
465 Citations1987George O'connor, David Sparrow +4 more
Dose-response slope is proposed as a quantitative measure of nonspecific airway responsiveness that avoids censoring and that may be particularly useful in epidemiologic studies.
Journal of Immunological MethodsA two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I
403 Citations1989Christina Luczynska, L. Karla Arruda +4 more
The Mab ELISA will be useful in epidemiological studies of allergic asthma, both in the assessment of levels of dust miteAllergen present in houses and the efficacy of allergen avoidance regimes.
The Journal of PediatricsRisk factors for asthma in inner city children
394 Citations1992Robert S. Call, Thomas F. Smith +3 more
The results show that black children in inner city Atlanta are exposed to high levels of mite and cockroach allergens and that a high proportion of the children with asthma are sensitized to these allergens; the combination of sensitization and exposure is a major risk factor for asthma in this population.
Journal of Allergy and Clinical ImmunologyEpidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits
346 Citations1989Susan M. Pollart, Martin D. Chapman +3 more
It is established that, with acute attacks of asthma as a marker for adult asthma, the presence of serum IgE Abs to common inhalant allergens is a major risk factor.
PubMedThe distribution of dust mite allergen in the houses of patients with asthma.
310 Citations1981Euan R. Tovey, Martin D. Chapman +2 more
The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allerGEN.
Journal of Allergy and Clinical ImmunologyQuantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: Relation to sensitization and asthma among children living in Los Alamos, New Mexico
307 Citations1995Jim Mark Ingram, Richard Sporik +4 more
The results show that in this mite-and cockroach-free environment sensitization to domestic animals was the most significant association with asthma and no clear relationship was found between sensitization or symptoms and the current level of allergen in individual houses.
PEDIATRICSRisk Factors for Acute Wheezing in Infants and Children: Viruses, Passive Smoke, and IgE Antibodies to Inhalant Allergens
289 Citations1993Angela L. Duff, Elaine S. Pomeranz +6 more
Recommendations to reduce tobacco smoke exposure at home, especially for young patients, and to consider sensitization to inhaled allergens and allergen avoidance in wheezing children at an early age, particularly after age 2 years are supported.
Clinical & Experimental AllergyBronchial hyperresponsiveness in two populations of Australian schoolchildren. I. Relation to respiratory symptoms and diagnosed asthma
282 Citations1987C. M. Salome, Jennifer Peat +2 more
It is concluded that cross‐sectional studies of BR to identify children with BHR probably do not reflect the prevalence of asthma in populations of children, and measurements of BR in populations are useful for defining a group of children whose airways behave differently from those of the majority.
American Journal of Respiratory and Critical Care MedicineAssociation of Asthma with Serum IgE and Skin Test Reactivity to Allergens among Children Living at High Altitude. Tickling the Dragon's Breath
252 Citations1995Richard Sporik, Jim Mark Ingram +4 more
The results show that in a mite-free environment with low levels of outdoor air pollution, asthma was still a major cause of morbidity among schoolchildren.
Journal of Allergy and Clinical ImmunologyEnvironmental exposure to cockroach allergens: Analysis with monoclonal antibody-based enzyme immunoassays
198 Citations1991Susan M. Pollart, Thomas F. Smith +4 more
The results demonstrate that CR may be an occult allergen in homes, and the kitchen appears to be the primary site of CR-allergen accumulation, but significant CR-Allergen levels can also be found at other sites in the home.
American Journal of Respiratory and Critical Care MedicineSensitization to Dust Mites as a Dominant Risk Factor for Asthma among Adolescents Living in Central Virginia
190 Citations1997Susan Pollart Squillace, Richard Sporik +6 more
In an area where there is a high prevalence of asthma and most houses contain high concentrations of dust mite allerGEN, sensitization to this allergen is the dominant risk factor for asthma defined as symptomatic bronchial hyperreactivity.
Journal of Allergy and Clinical ImmunologyRelevance of allergens from cats and dogs to asthma in the northernmost province of Sweden: Schools as a major site of exposure
182 Citations1999Matthew S. Perzanowski, Eva Rönmark +3 more
Serum IgE antibody assays on 165 children with respiratory symptoms confirmed that there was a high degree of sensitization to cat, dog, and birch in Northern Sweden, and the schools appear to be a major site of exposure to cat and dog allergy.
The LancetLinkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy
165 Citations1995Lynne van Herwerden, Stephen Harrap +7 more
It is suggested that mutations in the Fc epsilon RI beta gene or a closely linked gene influence the BHR underlying asthma, even in the absence of atopy.
Clinical & Experimental AllergyHouse dust mite and cat allergen in different indoor environments
147 Citations1994Adnan Čustović, S. Taggart +1 more
Upholstered seats from public buildings and public transport constitute anAllergen reservoir for continuous contamination of the indoor environment which could compromise the effects of allergen avoidance employed at home.
Journal of Allergy and Clinical ImmunologyIs there a dose-response relationship between exposure to indoor allergens and symptoms of asthma?
126 Citations1995Thomas A.E. Platts‐Mills, Richard Sporik +2 more
Journal of Allergy and Clinical ImmunologyExposure to indoor allergens in early infancy and sensitization
117 Citations1997A. K. M. Munir, N I Kjellman +1 more
Exposure to low levels of indoor allergens in early childhood is associated with a low incidence of sensitization, however, levels well below currently suggested threshold levels may cause sensitization in children with a family history of allergy.
Journal of Allergy and Clinical ImmunologyCat allergen (Fel d 1) levels on school children's clothing and in primary school classrooms in Wellington, New Zealand
114 Citations1997Kathryn Patchett, Simon Lewis +2 more
Carpeting should be discouraged in environments such as schools and child care centers, where children spend considerable time, and transport of Fel d 1 on clothing from the domestic to the school environment is a major source of classroom cat allergen.
Journal of Allergy and Clinical ImmunologySensitization to mite allergens is a risk factor for early and late onset of asthma and for persistence of asthmatic signs in children
100 Citations1995Joachim Kuehr, Thomas Frischer +6 more
The primary focus should be on preventing sensitization to mite allergens by implementing avoidance measures in infancy or at early school age in order to reduce the onset of asthma at a later stage.
Clinical & Experimental AllergyExposure to house dust mite allergen of children admitted to hospital with asthma
93 Citations1993Richard Sporik, Thomas A.E. Platts‐Mills +1 more
The majority of children admitted to hospital with exacerbations of asthma were exposed to housedust mite allergen and were house dust mite sensitive, and the results suggest that continued exposure to higher concentrations of miteAllergen may be associated with the risk of readmission.
Journal of Allergy and Clinical ImmunologyMite allergen (Der p 1) concentration in houses and its relation to the presence and severity of asthma in a population of Sydney schoolchildren
92 Citations1995Guy B. Marks, Euan R. Tovey +4 more
House dust mite (HDM) allergen exposure and its relation toHDM allergy and asthma was assessed in a case-control study conducted over three seasons in 74 Sydney schoolchildren, 33 of whom were allergic to HDM and 12 of whom had current asthma.
Clinical & Experimental AllergyMite (<i>Der p</i> I, <i>Der f</i> I), cat (<i>Fel d</i> I) and dog (<i>Can f</i> I) allergens in dust from Swedish day‐care centres
92 Citations1995A. K. M. Munir, R. Einarsson +1 more
Fel d I and Can f I allergens are ubiquitous in day‐care centres and the concentration of allergen in curtains reflects long‐term exposure to airborne indoor allergens, since they are mainly exposed to airborne allergens.
American Review of Respiratory DiseaseRelation of Dose-response Slope to Respiratory Symptoms in a Population of Australian Schoolchildren
64 Citations1991J. K. Peat, Cheryl M. Salome +2 more
It appears that DRS values are more useful than PD20 FEV1 values in epidemiologic studies of respiratory illness in children because a value that relates well to symptom history can be calculated for the entire sample.
Clinical & Experimental AllergyRelative risks of bronchial hyper‐responsiveness associated with skin‐prick test responses to common antigens in young adults
57 Citations1991WO Cookson, Nicholas de Klerk +3 more
The results show the risk of bronchial hyper‐responsiveness is greater in subjects sensitive to house dust and mould than in those reactive to grasses, and suggests that the presence or absence of increased NSBR in atopic individuals may depend on the antigens to which they become sensitized.
The LancetDetection of inhaled cat allergen
39 Citations1998T.J. O'Meara, Sandra D. De Lucca +3 more
A passive air sampler worn in each nostril which collects inhaled particles and a method that detects the allergen eluted from each particle is developed, showing that, at least for women with some oestrogen-receptor protein detectable on their primary tumour, patterns of tamoxifen use will continue to change.
Clinical & Experimental AllergyHouse dust mite allergen exposure in infancy
23 Citations1998Mahmic, Euan R. Tovey +2 more
Infancy may be a critical time for exposure to house dust mite allergens, when exposure to high levels can increase the risk of allergic sensitization and the development of asthma in later life.
Journal of Allergy and Clinical Immunology606 Exposure and sensitisation of children admitted to hospital with asthma to house dust mite allergen (Der p I)
7 Citations1991Richard Sporik, Thomas A.E. Platts‐Mills +1 more