Antigenic Cross‐Reactivity between Severe Acute Respiratory Syndrome–Associated Coronavirus and Human Coronaviruses 229E and OC43
The Journal of Infectious DiseasesPublished 20 May 2005Open access
Xiao‐yan Che, Li‐wen Qiu, Zhiyong Liao, Ya‐di Wang, Kun Wen, Yuxian Pan
Citations182
SJR quartileQ1
SJR score2.04
SNIP1.23
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TL;DR
Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs, and antigens of SARS-CoV and HCoV-OC43 were moreCross-reactive than were those of Sars-Cov and H coV-229E.
Abstract
Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.
Keywords
Agricultural and Biological SciencesMedicine
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