Transducin: an amplifier protein in vision
Trends in Biochemical SciencesPublished 1 January 1981
Lubert Stryer, James B. Hurley, B K Fung
Citations78
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
Retinal rod outer segments contain a light-activated cyclic GMP phosphodiesterase that triggers the exchange of GTP for GDP in hundreds of molecules of transducin, the amplified signal carrier in this activation process.
Abstract
Retinal rod outer segments contain a light-activated cyclic GMP phosphodiesterase. Transducin, a multisubunit protein, is the amplified signal carrier in this activation process. A photolyzed rhodopsin molecule triggers the exchange of GTP for GDP in hundreds of molecules of transducin. GTP-transducin then switches on the phosphodiesterase. Amplifiers like transducin may be present in many kinds of cells, as exemplified by the G-protein in the hormone-stimulated adenylate cyclase system.
Keywords
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