A Controlled Trial of Imipramine (“Tofranil”) in the Treatment of Severe Depressive States
Journal of Mental SciencePublished 1 May 1961
Linford Rees, A. C. Brown, S. Benaïm
Citations32
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
The discovery by Kuhn (1957) that an iminodibenzyl derivative (imipramine) was therapeutically successful in depressive illnesses aroused great interest and stimulated clinical trials with the drug in many parts of the world. The results of some of the published reports are given in summarized form in Table I.
Keywords
Medicine
American Journal of PsychiatryTHE TREATMENT OF DEPRESSIVE STATES WITH G 22355 (IMIPRAMINE HYDROCHLORIDE)
599 Citations1958Roland Kuhn
It was demonstrated that the compound has potent antidepressant action and best responses were obtained in cases of endogenous depression showing the typical symptoms of mental and motor retardation, fatigue, feeling of heaviness, hopelessness, guilt, and despair.
BMJA Controlled Trial of Imipramine in Treatment of Depressive States
125 Citations1959J. R. B. Ball, L. G. Kiloh
Information is provided on how to identify the components of serotonin, a substance which acts as a “spatially aggregating force” in women to increase the likelihood of fertility and increase the chance of pregnancy.