Antimycin-insensitive oxidation of succinate and reduced nicotinamide-adenine dinucleotide in electron-transport particles II. Steroid effects
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TL;DR
The effect of steroid appears to be associated with the formation of H 2 O 2 during antimycin-insensitive oxidation, which is a consequence of a steroid-induced shift in acid direction of the pH curve for antimycorticosterone-based oxidation.
Abstract
Antimycin-insensitive oxidation in electron-transport particles at physiological pH is inhibited by deoxycorticosterone with succinate as substrate. When the substrate is reduced nicotinamide-adenine dinucleotide and the steroid concentration is low, oxidation is stimulated, but high steroid concentrations are inhibitory. Amytal has similar effects. The divergence of the effect of steroid on the oxidation of reduced nicotinamide-adenine dinucleotide is a consequence of a steroid-induced shift in acid direction of the pH curve for antimycin-insensitive oxidation, where the magnitude of the shift depends on steroid concentration. The effect of steroid appears to be associated with the formation of H2O2 during antimycin-insensitive oxidation.