Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
Biological PsychiatryPublished 1 June 2002
Stephen M. Lawrie, Christian Buechel, Heather C. Whalley, Chris Frith, Karl Friston, Eve C. Johnstone
Citations534
SJR quartileQ1
SJR score4.68
SNIP2.24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations and previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements.
Abstract
Previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations.
Keywords
MedicineNeuroscience
Encyclopedia of Social WorkDiagnostic and Statistical Manual of Mental Disorders
109,983 Citations2013Janet B. W. Williams, Michael B. First
Clinical Neurology and NeurosurgeryCo-planar stereotaxic atlas of the human brain
7,606 Citations1989Lauri A. Laitinen
Schizophrenia BulletinThe Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
1,024 Citations1999Herbert Y. Meltzer, S. R. McGurk
Atypical antipsychotic drugs as a group appear to be superior to typical neuroleptics with regard to cognitive function, however, available data suggest that these drugs produce significant differences in specific cognitive functions.
NeuropsychologiaResponse suppression, initiation and strategy use following frontal lobe lesions
841 Citations1996Paul W. Burgess, Tim Shallice
Patients with frontal lobe involvement showed longer response latencies in the first condition and produced more words which were related to the sentence in the second, in comparison to patients with lesions elsewhere.
Acta Psychiatrica ScandinavicaA standardized psychiatric assessment scale for rating chronic psychotic patients
680 Citations1977M. Krawiecka, David Goldberg +1 more
Simple 5‐point scales are described together with the method used to study their reliability, the results of which are shown.
The British Journal of PsychiatryRegional Brain Activity in Chronic Schizophrenic Patients during the Performance of a Verbal Fluency Task
426 Citations1995Chris Frith, Karl Friston +7 more
Chronic schizophrenic patients can show a normal magnitude of frontal activation when matched for performance with controls, and they fail to show the expected reductions of activity in the superior temporal cortex, which may reflect abnormal functional connectivity between frontal and temporal cortex.
Philosophical Transactions of the Royal Society B Biological SciencesPrefrontal function in schizophrenia: confounds and controversies
413 Citations1996Daniel R. Weinberger, Karen F. Berman
Overall, the functional neuroimaging database in patients with schizophrenia suggests that prefrontal cognitive deficits are because of prefrontal pathophysiology and not the inverse.
Memory & CognitionCompletion norms for 329 sentence contexts
281 Citations1980Paul Alexander Bloom, Ira Fischler
Completion responses were collected for two sets of sentence contexts, which were designed to produce different distributions of probabilities for the primary responses.
American Journal of PsychiatryFunctional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production
243 Citations1996Deborah Yurgelun‐Todd, Christine Waternaux +4 more
The British Journal of PsychiatryFunctional anatomy of verbal fluency in people with schizophrenia and those at genetic risk
194 Citations2000Sean A. Spence, Peter F. Liddle +9 more
Failure of left STG ‘deactivation’ and left fronto-temporal disconnectivity are not consistent findings in schizophrenia; neither are they trait-markers for genetic risk.
American Journal of PsychiatryFunctional Anatomy of Auditory Verbal Imagery in Schizophrenic Patients With Auditory Hallucinations
181 Citations2000Sukhwinder S. Shergill, Edward T. Bullmore +3 more
Patients with schizophrenia who were prone to auditory hallucinations show attenuated activation when processing inner speech in areas implicated in verbal self-monitoring.
Journal of NeuroscienceLocal and Distributed Effects of Apomorphine on Fronto-Temporal Function in Acute Unmedicated Schizophrenia
167 Citations1996Paul C. Fletcher, Chris Frith +3 more
Overall, in schizophrenic subjects the effect of apomorphine, which is interpreted in terms of a net dopaminergic antagonism, was to modify the brain activity, making the pattern more akin to that seen in control subjects.
NeuropsychologiaThe functional anatomy of verbal initiation and suppression using the Hayling Test
144 Citations1997D.A. Nathaniel-James, Paul C. Fletcher +1 more
Journal of Neurology Neurosurgery & PsychiatryHypofrontality revisited: a high resolution single photon emission computed tomography study in schizophrenia.
59 Citations1995Klaus P. Ebmeier, Stephen M. Lawrie +3 more
Generalised hypofrontality is not a feature of schizophrenic patients at rest whether taking drugs or not and group differences in tracer uptake were predicted in anterior regions of interest.
