Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli
NaturePublished 1 April 1969
M. Ozaki, San-ichiro Mizushima, Michio Nomura
Citations460
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The streptomycin locus of E. coli specifies a 30S ribosomal protein which determines the sensitivity of the 30S subunit to strePTomycin and streptomecin induced errors of translation.
Abstract
The streptomycin locus of E. coli specifies a 30S ribosomal protein which determines the sensitivity of the 30S subunit to streptomycin and streptomycin induced errors of translation.
Keywords
Biochemistry, Genetics and Molecular Biology
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Property of the codeword recognition process and the minimum oligonucleotide chain length required to induce such interactions are presented, and the modification of RNA and DNA codewords, converting sense into missense or nonsense codewording, is suggested as a possible regulatory mechanism in protein synthesis.
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Analysis of the activity of these particles has revealed the functional significance of each of the purified ribosomal split proteins, supporting the hypothesis of spontaneous self assembly.
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352 Citations1966Philip Leder, H. Bursztyn
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198 Citations1964W. Szer, Severo Ochoa
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Aided by grants AM-01845, AM-08953, and FR-05399, this work is supported by grants from the National Institutes of Health, U.S. Public Health Service, and E. I. du Pont de Nemours and Co., Inc.
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