Delaying the initiation of intact breast irradiation for patients with lymph node positive breast cancer increases the risk of local recurrence
CancerPublished 15 December 1995
William F. Hartsell, Diane C. Recine, Katherine L. Griem, Anantha Murthy
Citations113
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
The impact of delaying irradiation to the intact breast for patients receiving chemotherapy for lymph node positive breast cancer is controversial and may have an adverse effect on survival.
Abstract
Delays in the initiation of irradiation are associated with increased risk of relapse in the breast. When possible, the interval between definitive breast surgery (lumpectomy or reexcision) and the initiation of radiation therapy should be fewer than 120 days.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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In patients requiring chemotherapy and radiation treatments for a local-regional breast cancer, a delay in the initiation of radiation for a period of 6 months or greater from diagnosis resulted in a higher local failure rate, associated with an increased rate of distant metastases and a decreased overall survival rate.
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