Determination of Left Ventricular Filling Pressure by Doppler Echocardiography in Patients With Coronary Artery Disease: Critical Role of Left Ventricular Systolic Function
Journal of the American College of CardiologyPublished 1 December 1997
Kazuhiro Yamamoto, Rick A. Nishimura, Hari P. Chaliki, Christopher P. Appleton, David R. Holmes, Margaret M. Redfield
Citations274
SJR quartileQ1
SJR score9.02
SNIP6.30
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Analysis of the early diastolic portion of the transmitral or pulmonary venous flow velocity curves can be used to predict LV filling pressures in patients with systolic dysfunction, but are inaccurate in patientsWith preserved syStolic function.
Abstract
Analysis of the early diastolic portion of the transmitral or pulmonary venous flow velocity curves can be used to predict LV filling pressures in patients with systolic dysfunction, but are inaccurate in patients with preserved systolic function. The combined analysis of both flow velocity curves at atrial contraction is a reliable, feasible predictor of increased LV filling pressure, irrespective of systolic function.
Keywords
Medicine
The American Journal of CardiologyEchocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
6,200 Citations1986Richard B. Devereux, Daniel R. Alonso +5 more
To determine the accuracy of echocardiographic left ventricular (LV) dimension and mass measurements for detection and quantification of LV hypertrophy, results of blindly read antemortem e chocardiograms were compared with LV mass measurements made at necropsy in 55 patients.
Journal of the American College of CardiologyRelation of transmitral flow velocity patterns to left ventricular diastolic function: New insights from a combined hemodynamic and Doppler echocardiographic study
1,570 Citations1988Christopher P. Appleton, Liv K. Hatle +1 more
Mitral flow velocity recordings have clinical potential in assessing left ventricular diastolic function that merits further investigation, despite the indirect method of estimation and certain limitations.
Journal of the American College of CardiologyEstimation of left ventricular filling pressures using two-dimensional and Doppler echocardiography in adult patients with cardiac disease
778 Citations1993Christopher P. Appleton, James M. Galloway +3 more
Mayo Clinic ProceedingsAssessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical Studies
753 Citations1989Rick A. Nishimura, Martin Abel +2 more
An interpretation of the mitral valve, tricuspid valve, and systemic and pulmonary venous inflow velocities in the normal patient and in various disease states is provided.
CirculationA new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography.
738 Citations1981Miguel A. Quiñones, Alan D. Waggoner +6 more
It is condude that EF can be determined accurately with 2‐D echo in a large group of patients with and without dyssynergy by a simple method that eliminates the need for planimetry or computer assistance.
Journal of the American College of CardiologyPreload dependence of doppler-derived indexes of left ventricular diastolic function in humans
628 Citations1987Christopher Y.P. Choong, Howard C. Herrmann +2 more
To determine the effect of filling pressure on the pattern of left ventricular filling in humans, the mitral flow velocity profile was measured by pulsed wave Doppler echocardiography during right and left heart catheterization in 11 patients before and during nitroglycerin infusion.
Journal of the American College of CardiologyPulmonary venous flow velocities recorded by transthoracic Doppler ultrasound: Relation to left ventricular diastolic pressures
623 Citations1993Ole Rossvoll, Liv K. Hatle
Investigation of pulmonary venous flow variables measured by transthoracic Doppler ultrasound can help identify patients with elevated left ventricular end-diastolic or filling pressures, or both indicates an exaggerated increase inleft ventricular late diastolic pressure.
The American Journal of CardiologyCongestive heart failure with normal systolic function
619 Citations1984Anne H. Dougherty, Gerald V. Naccarelli +3 more
Normal systolic function is common among patients with CHF, and diastolic dysfunction, consistent with a noncompliant left ventricle, was found in both CHF groups.
CirculationLeft ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure.
581 Citations1986Yasushi Ishida, Jay S. Meisner +5 more
PRFR is determined by both the left atrial pressure and the left ventricular relaxation rate and should be used with caution as an index ofleft ventricular diastolic function.
HypertensionSuperiority of Brain Natriuretic Peptide as a Hormonal Marker of Ventricular Systolic and Diastolic Dysfunction and Ventricular Hypertrophy
527 Citations1996Kazuhiro Yamamoto, John C. Burnett +6 more
An elevated plasma BNP was a more powerful marker ofleft ventricular systolic dysfunction, left ventricular diastolic function and left vent cardiac hypertrophy than C-terminal ANP or N-terminAL ANP-(1-30) in this population of patients with suspected cardiac disease.
The American Journal of CardiologyIntact systolic left ventricular function in clinical congestive heart failure
522 Citations1985Robert Soufer, Daniel Wohlgelernter +5 more
During a 3-month sampling period 42% of patients with clinical diagnosis of CHF referred to the nuclear cardiology laboratory were found to have intact syStolic function; thus, intact systolic function is not uncommon in patients withclinical CHF.
CirculationRelation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditions.
499 Citations1990Rick A. Nishimura, Martin Abel +2 more
This study relates changes in pulmonary venous and mitral flow velocities during different loading conditions as assessed by transesophageal echocardiography in the operating room to indicate that diastolic flow velocity in the pulmonary vein is determined by the same factors that influence theMitral flow velocity curves.
CirculationSystolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis.
443 Citations1994Charanjit S. Rihal, Rick A. Nishimura +3 more
In patients with the clinical diagnosis of dilated cardiomyopathy, markers of diastolic dysfunction correlated strongly with congestive symptoms, whereas variables of systolic function were the strongest predictors of survival.
CirculationEstimation of mean left atrial pressure from transesophageal pulsed Doppler echocardiography of pulmonary venous flow.
441 Citations1990Helmut F. Kuecherer, Isobel A. Muhiudeen +5 more
Journal of the American College of CardiologyRestrictive left ventricular filling pattern in dilated cardiomyopathy assessed by doppler echocardiography: Clinical, echocardiographic and hemodynamic correlations and prognostic implications
439 Citations1993Bruno Pinamonti, Andrea Di Lenarda +2 more
Restrictive left ventricular filling pattern is frequent in dilated cardiomyopathy, is associated with more severe disease and is a powerful indicator of increased mortality risk and need for heart transplantation.
CirculationEchocardiographic Doppler evaluation of left ventricular diastolic function. Physics and physiology.
417 Citations1991James D. Thomas, Arthur E. Weyman
The ventricular filling pattern was initially obtained from ventricular volumes obtained from radionuclide ventriculograms10l1 and M-mode and two-dimensional echocardiograms, which were time-differentiated to yield filling rate throughout diastole.
CirculationCombined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measured by Doppler echocardiography.
413 Citations1988Christopher Y.P. Choong, Vivian M. Abascal +4 more
Stepwise multiple linear regression analysis of data pooled from all experimental stages in all dogs identified left atrial V-wave pressure, the time constant of relaxation (TL), and left ventricular systolic pressure, in order of decreasing significance, as predictors of the peak E-wave velocity (n = 82, multiple r = 0.87, p less than 0.0001).
Annals of Internal MedicineLeft Ventricular Diastolic Dysfunction as a Cause of Congestive Heart Failure
400 Citations1992Robert O. Bonow, James E. Udelson
Diastolic dysfunction should be considered in the patient presenting with heart failure symptoms but with normal systolic function, particularly in hypertensive patients with left ventricular hypertrophy.
Circulation ResearchDeterminants of left ventricular filling and of the diastolic pressure-volume relation.
365 Citations1989John Gilbert, Stanton A. Glantz
It is learned that many factors can affect left ventricular filling and the diastolic pressure-volume relation acutely, and the original concept that the pressure within the left ventricle is determined by the balance between the forces due to pressures within the ventricular cavity that expand the ventrical cavity and forcesDue to elasticity of the myocardium that resist this expan-
Journal of the American College of CardiologyDoppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction
364 Citations1994Pantaleo Giannuzzi, Alessandro Imparato +5 more
Doppler-derived mitral deceleration time of early filling provides a simple and accurate means of estimating pulmonary capillary wedge pressure that is particularly useful in patients with a normal or normalized mitral flow velocity pattern.
Journal of the American College of CardiologyNoninvasive doppler echocardiographic evaluation of left ventricular filling pressures in patients with cardiomyopathies: A simultaneous doppler echocardiographic and cardiac catheterization study
360 Citations1996Rick A. Nishimura, Christopher P. Appleton +4 more
Doppler echocardiographic mitral flow velocity curves are useful in predicting and estimatingleft ventricular filling pressures in patients with left ventricular dysfunction, but because of the complexity of the multiple interrelated factors that determine diastolic filling of the left ventricle, they cannot be used in patientsWith other disease entities, such as hypertrophic cardiomyopathy.
CirculationMechanism of altered patterns of left ventricular filling during the development of congestive heart failure.
313 Citations1994M Ohno, C P Cheng +1 more
Observed changes in early filling rates suggest that the early filling deceleration time reflects LV stiffness, which is overcome by an increase in LA pressure that augments the early diastolic LA-LV pressure gradient, increasing peak early filling rate.
Mayo Clinic ProceedingsEffects of Age on Left Ventricular Dimensions and Filling Dynamics in 117 Normal Persons
308 Citations1994Allan L. Klein, D. Burstow +4 more
This study confirms the major influence of the aging process on left ventricular diastolic function in a large series of normal subjects and recommends this physiologic factor should be considered in Doppler assessment ofleft ventricularDiastolic filling in future studies.
Journal of the American Society of EchocardiographyDoppler Assessment of Pulmonary Venous Flow in Healthy Subjects and in Patients with Heart Disease
263 Citations1991Allan L. Klein, A. Jamil Tajik
The utility, physiology, and technique of measuring pulmonary venous flow with Doppler echocardiography with transesophageal echOCardiography in health and in disease is emphasized.
EchocardiographyThe Natural History of Left Ventricular Filling Abnormalities: Assessment by Two‐Dimensional and Doppler Echocardiography
247 Citations1992Christopher P. Appleton, Liv K. Hatle
A progression of LV filling abnormalities is presented in the sequential “stages” in which it is believed they occur in most cardiac disease states.
CirculationMitral anulus motion. Relation to pulmonary venous and transmitral flows in normal subjects and in patients with dilated cardiomyopathy.
238 Citations1988Gad Keren, Edmund H. Sonnenblick +1 more
European Heart JournalEchocardiographic assessment of left ventricular hypertrophy
232 Citations1982Nathaniel Reichek
The concepts built up during the extensive study of left ventricular disorders by echocardiography will be relevant to newer techniques such as computerised roentgenographic and positron emission tomography and nuclear magnetic resonance when they are applied in the same situations.
Journal of the American College of CardiologyEstimation of left ventricular end-diastolic pressure from Doppler transmitral flow velocity in cardiac patients independent of systolic performance
215 Citations1992Sharon L. Mulvagh, Miguel A. Quiñones +3 more
This investigation explored the hypothesis that combining isovolumetric relaxation time with measurements derived from the transmitral flow velocity can be used to estimate left ventricular end-diastolic pressure.
Circulation ResearchAltered left atrial compliance after atrial appendectomy. Influence on left atrial and ventricular filling.
173 Citations1993Brian D. Hoit, Y Shao +4 more
The hypothesis thatleft atrial compliance is decreased after removal of the left atrial appendage and the effect of altered atrial Compliance on atrial reservoir and conduit function is tested and the systolic to diastolic flow integral ratio of pulmonary venous flow increased significantly with volume infusion only before appendectomy; at matched left atrium pressure, JFTI/KFTI was significantly less afterwards.
CirculationAre contraction and relaxation coupled in patients with and without congestive heart failure
140 Citations1992E JEichhorn, J EWillard +5 more
CirculationAre contraction and relaxation coupled in patients with and without congestive heart failure?
138 Citations1992Eric J. Eichhorn, J E Willard +5 more
American Journal of Physiology-Heart and Circulatory PhysiologyPhysical and physiological determinants of transmitral velocity: numerical analysis
106 Citations1991James D. Thomas, J B Newell +2 more
It is found that the peak mitral velocity is most strongly related to initial left atrial pressure but lowered by prolonged relaxation, low atrial and ventricular compliance, and systolic dysfunction.
HeartAnalysis of left ventricular diastolic function
105 Citations1996Kazuyoshi Yamamoto, Margaret M. Redfield +1 more
There are still limitations with the non-invasive assessment of left ventricular diastolic function and filling pressures by Doppler echocardiography, but great progress has been made and careful interpretation of properly obtained Dopplers recordings can give clinically relevant information concerning left Ventricular diastsolic function, filling pressures, and prognosis in patients with cardiac disease.
The American Journal of CardiologyUsefulness of Doppler echocardiography in the diagnosis of congestive heart failure
101 Citations1989Frank V. Aguirre, Anthony C. Pearson +3 more
Evaluation of left ventricular function and of causative mechanisms of CHF before initiation of long-term treatment is mandatory and clinical differentiation of this group of patients from those with abnormalleft ventricular systolic function was difficult.
CirculationNoninvasive measurement of rate of left ventricular relaxation by Doppler echocardiography. Validation with simultaneous cardiac catheterization.
98 Citations1993Rick A. Nishimura, Robert S. Schwartz +2 more
The descending limb of the Doppler-derived mitral regurgitation velocity signal can be used as a semiquantitative estimate of the rate of ventricular relaxation in humans by comparing it with simultaneous high-fidelity left ventricular pressure measurements in humans.
Journal of the American College of CardiologyFailure of calcium channel blockers to improve ventricular relaxation in humans
90 Citations1993Rick A. Nishimura, Robert S. Schwartz +2 more
There was an increase in left ventricular end-diastolic pressure as well as an overall prolongation of the time constant of relaxation, suggesting changes in peak filling rates do not accurately reflect the response of ventricular relaxation to drug interactions.
Journal of the American Society of EchocardiographyAssessment of left ventricular end-diastolic pressure by Doppler echocardiography: Contribution of duration of pulmonary venous versus mitral flow velocity curves at atrial contraction
86 Citations1997Kazuhiro Yamamoto, Rick A. Nishimura +2 more
Pulmonary venous and mitral A durations are related to ventricular compliance and they change in an opposite and progressive manner, which is a sensitive method for the detection of the elevated end-diastolic pressure associated with reduction in ventricular Compliance.
CirculationChange of left atrial systolic pressure waveform in relation to left ventricular end-diastolic pressure.
82 Citations1990Yasuo Matsuda, Y Toma +8 more
The relation between the left atrial systolic pressure waveform and left ventricular end-diastolic pressure was observed in 17 patients who underwent diagnostic cardiac catheterization and it is suggested that the second (A') wave might be attributed to the increased reflection associated with increasedleft ventricularend-diastsolic pressure.
Journal of the American College of CardiologyImportance of left ventricular minimal pressure as a determinant of transmitral flow velocity pattern in the presence of left ventricular systolic dysfunction
64 Citations1993Kazuhiro Yamamoto, Tohru Masuyama +7 more
Preload dependency of the Doppler transmitral flow velocity pattern is hampered if an increase in left atrial pressure is due to left ventricular systolic dysfunction.
American Heart JournalDoppler echocardiographic pulmonary venous flow-velocity pattern for assessment of the hemodynamic profile in acute congestive heart failure
50 Citations1995Tohru Masuyama, Jung‐Myung Lee +8 more
Two primary sets of hemodynamic parameters, that is, left atrial pressure and cardiac output, can be estimated with Doppler pulmonary venous flow parameters in patients with acute CHF by using the transthoracic approach.
CirculationNoninvasive Assessment of Left Ventricular Relaxation Using Continuous-Wave Doppler Aortic Regurgitant Velocity Curve
44 Citations1995Kazuhiro Yamamoto, Tohru Masuyama +8 more
Whether analysis of continuous-wave Doppler aortic regurgitation recording provides accurate measures of LV relaxation over a wide range of LV function is clarified and comparative values of aorta and mitral regurgitant methods in the assessment of LV Relaxation are determined.
Cardiovascular ResearchEffects of heart rate on left ventricular filling dynamics: assessment from simultaneous recordings of pulsed Doppler transmitral flow velocity pattern and haemodynamic variables
43 Citations1993Kazuhiro Yamamoto, T Masuyama +6 more
This change in transmitral flow velocity pattern changes with altering heart rate is not considered to be a direct effect of alteration in heart rate, but an indirect one through the associated haemodynamic changes including left atrial pressure and left ventricular relaxation and contractility.
Journal of the American Society of EchocardiographyTransthoracic doppler echocardiographic measurements of pulmonary venous flow velocity patterns: Comparison with transesophageal measurements
35 Citations1995Tohru Masuyama, Reiko Nagano +8 more
Transthoracic measurements of the pulmonary venous flow velocity pattern are feasible and accurate in patients and may be used to assess left ventricular function and hemodynamics as a substitute for transesophageal measurements.
American Heart JournalIntraventricular dispersion of early diastolic filling: A new marker of left ventricular diastolic dysfunction
30 Citations1995Kazuhiro Yamamoto, Tohru Masuyama +7 more
The assessment of the intraventricular decrease in peak early diastolic flow velocity may be useful in detecting LV diastolics dysfunction, particularly in patients with Af or a "normalized" mitral flow velocity pattern.
Journal of the American Society of EchocardiographyPeak Early Diastolic Filling Velocity May Decrease With Preload Augmentation: Effect of Concomitant Increase in the Rate of Left Atrial Pressure Drop in Early Diastole
20 Citations1993Kazuhiro Yamamoto, Tohru Masuyama +7 more
P pulsed Doppler transmitral flow velocity pattern and high-fidelity LA and left ventricular pressures were simultaneously recorded during rapid volume loading to the LA to suggest that at high LA pressure the increased rate of LA pressure drop in early diastole appears to decrease LV filling and hence to reduce stroke volume.
Medical Entomology and ZoologyThe Echo Manual: From the Mayo Clinic
9 Citations1994Jae K. Oh, J.B. Seward +1 more
A useful "hands-on" guide in the lab or clinic which features reference tables of normal values and draws on extensive case material to give a wide-ranging overview of many conditions.